Serological profiling of group A Streptococcus infections in acute rheumatic fever

Natalie Lorenz, Timothy K C Ho, Reuben McGregor, Mark R Davies, Deborah A Williamson, Jason K Gurney, Pierre R Smeesters, Michael G Baker, Nicole J Moreland*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Rheumatic fever is a serious post-infectious sequela of group A Streptococcus (GAS). Prior GAS exposures were mapped in sera using a large panel of M-type specific peptides. Rheumatic fever patients had serological evidence of significantly more GAS exposures than matched controls suggesting immune priming by repeat infections contributes to pathogenesis.

Original languageEnglish
Pages (from-to)2322-2325
Number of pages4
JournalClinical Infectious Diseases
Volume73
Issue number12
Early online date30 Apr 2021
DOIs
Publication statusPublished - 15 Dec 2021

Keywords

  • Antigens, Bacterial
  • Humans
  • Rheumatic Fever/complications
  • Streptococcal Infections/complications
  • Streptococcus pyogenes

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