Sequence comparison between the haemagglutinin-neuraminidase genes of simian, canine and human isolates of simian virus 5

DU Baty; JA Southern; Richard Edward Randall

Sequence comparison between the haemagglutinin-neuraminidase genes of simian, canine and human isolates of simian virus 5

DU Baty, JA Southern, Richard Edward Randall

Research output: Contribution to journal › Article › peer-review

Abstract

The nucleotide sequence of the haemagglutinin-neuraminidase (HN) gene was determined for a simian (W3), human (LN) and two canine (CPI+/CPI-) isolates of simian virus 5 (SV5). A comparison of the predicted amino acid sequences revealed that the human and canine isolates varied from the simian isolate by 1.7% and 2.4% respectively. This lack of significant variation between the HN proteins of the four SV5 isolates suggests that insufficient differences have occurred between isolates to confine them to a specific host.

Original language	English
Pages (from-to)	3103-7
Number of pages	5
Journal	Journal of General Virology
Volume	72
Publication status	Published - Dec 1991

Keywords

NEWCASTLE-DISEASE VIRUS
NUCLEOTIDE-SEQUENCE
MONOCLONAL-ANTIBODIES
MESSENGER-RNA
HN GENE
PARAMYXOVIRUS
PROTEIN
EVOLUTION
COMPLEX
TYPE-2

Cite this

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title = "Sequence comparison between the haemagglutinin-neuraminidase genes of simian, canine and human isolates of simian virus 5",

abstract = "The nucleotide sequence of the haemagglutinin-neuraminidase (HN) gene was determined for a simian (W3), human (LN) and two canine (CPI+/CPI-) isolates of simian virus 5 (SV5). A comparison of the predicted amino acid sequences revealed that the human and canine isolates varied from the simian isolate by 1.7\% and 2.4\% respectively. This lack of significant variation between the HN proteins of the four SV5 isolates suggests that insufficient differences have occurred between isolates to confine them to a specific host.",

keywords = "NEWCASTLE-DISEASE VIRUS, NUCLEOTIDE-SEQUENCE, MONOCLONAL-ANTIBODIES, MESSENGER-RNA, HN GENE, PARAMYXOVIRUS, PROTEIN, EVOLUTION, COMPLEX, TYPE-2",

author = "DU Baty and JA Southern and Randall, \{Richard Edward\}",

year = "1991",

month = dec,

language = "English",

volume = "72",

pages = "3103--7",

journal = "Journal of General Virology",

issn = "0022-1317",

publisher = "Microbiology Society",

}

TY - JOUR

T1 - Sequence comparison between the haemagglutinin-neuraminidase genes of simian, canine and human isolates of simian virus 5

AU - Baty, DU

AU - Southern, JA

AU - Randall, Richard Edward

PY - 1991/12

Y1 - 1991/12

N2 - The nucleotide sequence of the haemagglutinin-neuraminidase (HN) gene was determined for a simian (W3), human (LN) and two canine (CPI+/CPI-) isolates of simian virus 5 (SV5). A comparison of the predicted amino acid sequences revealed that the human and canine isolates varied from the simian isolate by 1.7% and 2.4% respectively. This lack of significant variation between the HN proteins of the four SV5 isolates suggests that insufficient differences have occurred between isolates to confine them to a specific host.

AB - The nucleotide sequence of the haemagglutinin-neuraminidase (HN) gene was determined for a simian (W3), human (LN) and two canine (CPI+/CPI-) isolates of simian virus 5 (SV5). A comparison of the predicted amino acid sequences revealed that the human and canine isolates varied from the simian isolate by 1.7% and 2.4% respectively. This lack of significant variation between the HN proteins of the four SV5 isolates suggests that insufficient differences have occurred between isolates to confine them to a specific host.

KW - NEWCASTLE-DISEASE VIRUS

KW - NUCLEOTIDE-SEQUENCE

KW - MONOCLONAL-ANTIBODIES

KW - MESSENGER-RNA

KW - HN GENE

KW - PARAMYXOVIRUS

KW - PROTEIN

KW - EVOLUTION

KW - COMPLEX

KW - TYPE-2

UR - https://www.scopus.com/pages/publications/0026327188

M3 - Article

SN - 0022-1317

VL - 72

SP - 3103

EP - 3107

JO - Journal of General Virology

JF - Journal of General Virology

ER -

Sequence comparison between the haemagglutinin-neuraminidase genes of simian, canine and human isolates of simian virus 5

Abstract

Keywords

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