Self-assembled hexasaccharides: Surface characterization of thiol-terminated sugars adsorbed on a gold surface

Michaela C. Fritz, Georg Hähner*, Nicholas D. Spencer, Roland Bürli, Andrea Vasella

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

39 Citations (Scopus)

Abstract

A thiol-terminated hexasaccharide, protected with acetyl groups (AHS) was synthesized for the purpose of depositing self-assembled monolayers (SAMs) from solution onto gold surfaces. X-ray photoelectron spectroecopy (XPS), ellipsometry, contact angle measurements, and imaging time-of-flight seconder) ion mass spectroecopy (iToF-SIMS) were used to determine coverage, homogeneity, chemical composition, film thicknesses, and kinetics of film growth. Deprotection of the molecules, i.e. replacing acetoxy groups by hydroxyl groups, was performed following adsorption of AHS onto the surface, as well as prior to adsorption from solution. The chemical composition of the resulting films, the film thickness, the density of molecules, and the nature of the surface functional groups were determined. Adsorption of the deprotected molecules (DHS) from solution was found to lead to a higher density of adsorbed species.

Original languageEnglish
Pages (from-to)6074-6082
Number of pages9
JournalLangmuir
Volume12
Issue number25
Publication statusPublished - 11 Dec 1996

Fingerprint

Dive into the research topics of 'Self-assembled hexasaccharides: Surface characterization of thiol-terminated sugars adsorbed on a gold surface'. Together they form a unique fingerprint.

Cite this