Selective NaOH-catalysed hydration of aromatic nitriles to amides

Thibault Schmid; Alberto Gomez Herrera; Olivier Songis; Deborah  Sneddon; Antoine  Révolte; Fady Nahra; Catherine S.J. Cazin

doi:10.1039/C5CY00313J

Selective NaOH-catalysed hydration of aromatic nitriles to amides

Thibault Schmid, Alberto Gomez Herrera, Olivier Songis, Deborah Sneddon , Antoine Révolte , Fady Nahra, Catherine S.J. Cazin

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Abstract

The selective synthesis of aromatic and heteroaromatic amides through base-catalysed hydration of nitriles was achieved using inexpensive and commercially available NaOH as the only catalyst. A wide range of nitriles was selectively converted to their corresponding amides. Kinetic studies show that the double hydration of nitriles towards undesirable carboxylic acids is negligible under our reaction conditions.

Original language	English
Pages (from-to)	2865-2868
Journal	Catalysis Science & Technology
Volume	5
Issue number	5
Early online date	24 Mar 2015
DOIs	https://doi.org/10.1039/C5CY00313J
Publication status	Published - 1 May 2015

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10.1039/C5CY00313J

FN_catscitech_hydration_of_nitriles_170315_MS[1]
Copyright 2015 the Authors. This work is made available online in accordance with the publisher’s policies. This is the author created, accepted version manuscript following peer review and may differ slightly from the final published version. The final published version of this work is available at https://dx.doi.org/10.1039/C5CY00313J.
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abstract = "The selective synthesis of aromatic and heteroaromatic amides through base-catalysed hydration of nitriles was achieved using inexpensive and commercially available NaOH as the only catalyst. A wide range of nitriles was selectively converted to their corresponding amides. Kinetic studies show that the double hydration of nitriles towards undesirable carboxylic acids is negligible under our reaction conditions.",

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AU - Schmid, Thibault

AU - Gomez Herrera, Alberto

AU - Songis, Olivier

AU - Sneddon , Deborah

AU - Révolte , Antoine

AU - Nahra, Fady

AU - Cazin, Catherine S.J.

N1 - The authors gratefully acknowledge the Royal Society (University Research Fellowship to CSJC)

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N2 - The selective synthesis of aromatic and heteroaromatic amides through base-catalysed hydration of nitriles was achieved using inexpensive and commercially available NaOH as the only catalyst. A wide range of nitriles was selectively converted to their corresponding amides. Kinetic studies show that the double hydration of nitriles towards undesirable carboxylic acids is negligible under our reaction conditions.

AB - The selective synthesis of aromatic and heteroaromatic amides through base-catalysed hydration of nitriles was achieved using inexpensive and commercially available NaOH as the only catalyst. A wide range of nitriles was selectively converted to their corresponding amides. Kinetic studies show that the double hydration of nitriles towards undesirable carboxylic acids is negligible under our reaction conditions.

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ER -

Selective NaOH-catalysed hydration of aromatic nitriles to amides

Abstract

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Catalytic C-H bond functionalisation: Catalytic C-H bond functionalisation

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Selective NaOH-catalysed hydration of aromatic nitriles to amides

Abstract

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Catalytic C-H bond functionalisation: Catalytic C-H bond functionalisation

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