This article analyzes why and how women’s sex work is securitized in Tajikistan. It argues that state actors view sex work as a threat to the nation in the context of two simultaneous processes: nation-building, centered around the family unit, and the fight against HIV/AIDS. The article explores the narratives, laws, and practices that are deployed to limit sex work. It also analyzes how security frameworks are experienced and navigated by women sex workers on a very local level. Three coping strategies are identified: hiding techniques, developing networks and befriending influential clients, and seeking companionship with other sex workers.