Screening and synthesis: high throughput technologies applied to parasitology

R E Morgan, N J Westwood

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

High throughput technologies continue to develop in response to the challenges set by the genome projects. This article discusses how the techniques of both high throughput screening (HTS) and synthesis can influence research in parasitology. Examples of the use of targeted and phenotype-based HTS using unbiased compound collections are provided. The important issue of identifying the protein target(s) of bioactive compounds is discussed from the synthetic chemist's perspective. This article concludes by reviewing recent examples of successful target identification studies in parasitology.

Original languageEnglish
Number of pages9
JournalParasitology
Volume128
DOIs
Publication statusPublished - 2004

Keywords

  • high throughput screening
  • automated synthesis
  • affinity chromatography
  • protozoan
  • review
  • technology
  • target identification
  • chemical genetics
  • compound collection
  • phenotypic assay
  • DEPENDENT PROTEIN-KINASE
  • DIHYDROFOLATE-REDUCTASE
  • PLASMODIUM-FALCIPARUM
  • TOXOPLASMA-GONDII
  • TRYPANOSOMA-CRUZI
  • DRUG DISCOVERY
  • TRYPANOTHIONE REDUCTASE
  • CHEMICAL GENETICS
  • INHIBITORS
  • IDENTIFICATION

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