Same-day smears in the diagnosis of tuberculosis

S Hirao; M A Yassin; H G Khamofu; L Lawson; A Cambanis; A Ramsay; L E Cuevas

doi:10.1111/j.1365-3156.2007.01952.x

Same-day smears in the diagnosis of tuberculosis

S Hirao, M A Yassin, H G Khamofu, L Lawson, A Cambanis, A Ramsay, L E Cuevas

Research output: Contribution to journal › Article › peer-review

Abstract

OBJECTIVE: To assess the feasibility of completing the diagnosis of tuberculosis (TB) in 1 day by collecting only on-the-spot specimens.

METHODS: Individuals with suspected TB attending district hospitals in Abuja submitted three sputum samples for routine diagnosis (the standard approach). One additional sample was collected 1 h after the first sputum (the same-day approach). One sputum sample was cultured. Blood samples were tested for HIV.

RESULTS: Two hundred and twenty-four patients with chronic cough had 135/672 (20%) positive on-the-spot smears and 47/224 (21%) positive morning smears. The same-day and internationally recommended approaches identified 44 and 45 of the 78 patients with positive cultures, respectively. 106/194 (55%) patients were HIV positive. Only 9-11% of their smears were positive compared with 30-32% for HIV negatives (P < 0.01).

CONCLUSION: It could be possible to diagnose TB in a single day by examining two spot specimens, but the feasibility needs to be confirmed on a larger scale.

Original language	English
Pages (from-to)	1459-63
Number of pages	5
Journal	Tropical Medicine and International Health
Volume	12
Issue number	12
DOIs	https://doi.org/10.1111/j.1365-3156.2007.01952.x
Publication status	Published - Dec 2007

Keywords

Adolescent
Adult
Age Distribution
Cross-Sectional Studies
Feasibility Studies
Female
HIV Seropositivity/blood
Humans
Male
Middle Aged
Nigeria/epidemiology
Sputum/microbiology
Time Factors
Tuberculosis/diagnosis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/j.1365-3156.2007.01952.x

Cite this

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title = "Same-day smears in the diagnosis of tuberculosis",

abstract = "OBJECTIVE: To assess the feasibility of completing the diagnosis of tuberculosis (TB) in 1 day by collecting only on-the-spot specimens.METHODS: Individuals with suspected TB attending district hospitals in Abuja submitted three sputum samples for routine diagnosis (the standard approach). One additional sample was collected 1 h after the first sputum (the same-day approach). One sputum sample was cultured. Blood samples were tested for HIV.RESULTS: Two hundred and twenty-four patients with chronic cough had 135/672 (20%) positive on-the-spot smears and 47/224 (21%) positive morning smears. The same-day and internationally recommended approaches identified 44 and 45 of the 78 patients with positive cultures, respectively. 106/194 (55%) patients were HIV positive. Only 9-11% of their smears were positive compared with 30-32% for HIV negatives (P < 0.01).CONCLUSION: It could be possible to diagnose TB in a single day by examining two spot specimens, but the feasibility needs to be confirmed on a larger scale.",

keywords = "Adolescent, Adult, Age Distribution, Cross-Sectional Studies, Feasibility Studies, Female, HIV Seropositivity/blood, Humans, Male, Middle Aged, Nigeria/epidemiology, Sputum/microbiology, Time Factors, Tuberculosis/diagnosis",

author = "S Hirao and Yassin, {M A} and Khamofu, {H G} and L Lawson and A Cambanis and A Ramsay and Cuevas, {L E}",

year = "2007",

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doi = "10.1111/j.1365-3156.2007.01952.x",

language = "English",

volume = "12",

pages = "1459--63",

journal = "Tropical Medicine and International Health",

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T1 - Same-day smears in the diagnosis of tuberculosis

AU - Hirao, S

AU - Yassin, M A

AU - Khamofu, H G

AU - Lawson, L

AU - Cambanis, A

AU - Ramsay, A

AU - Cuevas, L E

PY - 2007/12

Y1 - 2007/12

N2 - OBJECTIVE: To assess the feasibility of completing the diagnosis of tuberculosis (TB) in 1 day by collecting only on-the-spot specimens.METHODS: Individuals with suspected TB attending district hospitals in Abuja submitted three sputum samples for routine diagnosis (the standard approach). One additional sample was collected 1 h after the first sputum (the same-day approach). One sputum sample was cultured. Blood samples were tested for HIV.RESULTS: Two hundred and twenty-four patients with chronic cough had 135/672 (20%) positive on-the-spot smears and 47/224 (21%) positive morning smears. The same-day and internationally recommended approaches identified 44 and 45 of the 78 patients with positive cultures, respectively. 106/194 (55%) patients were HIV positive. Only 9-11% of their smears were positive compared with 30-32% for HIV negatives (P < 0.01).CONCLUSION: It could be possible to diagnose TB in a single day by examining two spot specimens, but the feasibility needs to be confirmed on a larger scale.

AB - OBJECTIVE: To assess the feasibility of completing the diagnosis of tuberculosis (TB) in 1 day by collecting only on-the-spot specimens.METHODS: Individuals with suspected TB attending district hospitals in Abuja submitted three sputum samples for routine diagnosis (the standard approach). One additional sample was collected 1 h after the first sputum (the same-day approach). One sputum sample was cultured. Blood samples were tested for HIV.RESULTS: Two hundred and twenty-four patients with chronic cough had 135/672 (20%) positive on-the-spot smears and 47/224 (21%) positive morning smears. The same-day and internationally recommended approaches identified 44 and 45 of the 78 patients with positive cultures, respectively. 106/194 (55%) patients were HIV positive. Only 9-11% of their smears were positive compared with 30-32% for HIV negatives (P < 0.01).CONCLUSION: It could be possible to diagnose TB in a single day by examining two spot specimens, but the feasibility needs to be confirmed on a larger scale.

KW - Adolescent

KW - Adult

KW - Age Distribution

KW - Cross-Sectional Studies

KW - Feasibility Studies

KW - Female

KW - HIV Seropositivity/blood

KW - Humans

KW - Male

KW - Middle Aged

KW - Nigeria/epidemiology

KW - Sputum/microbiology

KW - Time Factors

KW - Tuberculosis/diagnosis

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DO - 10.1111/j.1365-3156.2007.01952.x

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SN - 1360-2276

VL - 12

SP - 1459

EP - 1463

JO - Tropical Medicine and International Health

JF - Tropical Medicine and International Health

IS - 12

ER -

Same-day smears in the diagnosis of tuberculosis

Abstract

Keywords

UN SDGs

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