Role of type-specific neuron properties in a spinal cord motor network

B. Sautois, S.R. Soffe, Wenchang Li, A. Roberts

Research output: Contribution to journalArticlepeer-review

35 Citations (Scopus)

Abstract

Recent recordings from spinal neurons in hatchling frog tadpoles allow their type-specific properties to be defined. Seven main types of neuron involved in the control of swimming have been characterized. To investigate the significance of type-specific properties, we build models of each neuron type and assemble them into a network using known connectivity between: sensory neurons, sensory pathway interneurons, central pattern generator (CPG) interneurons and motoneurons. A single stimulus to a sensory neuron initiates swimming where modelled neuronal and network activity parallels physiological activity. Substitution of firing properties between neuron types shows that those of excitatory CPG interneurons are critical for stable swimming. We suggest that type-specific neuronal properties can reflect the requirements for involvement in one particular network response (like swimming), but may also reflect the need to participate in more than one response (like swimming and slower struggling).

Original languageEnglish
Pages (from-to)59-77
Number of pages19
JournalJournal of Computational Neuroscience
Volume23
Issue number1
DOIs
Publication statusPublished - Aug 2007

Keywords

  • Tadpole model
  • Swimming
  • CPG
  • Type-specificity
  • NMDA
  • HATCHLING XENOPUS TADPOLES
  • GLYCINERGIC INHIBITION
  • SEGMENTAL COORDINATION
  • RECIPROCAL INHIBITION
  • RHYTHM GENERATION
  • PATTERN GENERATOR
  • SIMPLE VERTEBRATE
  • LARVAL ZEBRAFISH
  • SENSORY PATHWAYS
  • NMDA RECEPTORS

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