TY - JOUR
T1 - Role of TRAF3 in neurological and cardiovascular diseases
T2 - An overview of recent studies
AU - Cullell, Natalia
AU - Muiño, Elena
AU - Carrera, Caty
AU - Torres, Nuria
AU - Krupinski, Jerzy
AU - Fernandez-Cadenas, Israel
N1 - Funding Information:
Acknowledgements: This work was supported by a grant from the Carlos III Institute of Health (PI15/01978) and by Boehringer Ingelheim funding. We thank the International Stroke Genetics Consortium (ISGC), the Spanish Stroke Genetics Consortium (www.genestroke.com) and the RETICS Network INVICTUS, which The Neurovascular Pharmacogenomics and Genetics Laboratory are part of.
Publisher Copyright:
© 2018 Walter de Gruyter GmbH. All rights reserved.
PY - 2017/9
Y1 - 2017/9
N2 - Tumour necrosis factor receptor-associated factor 3 (TRAF3) is a member of the TRAF adaptor protein family, which exerts different effects on the cell depending on the receptor to which it binds and the cell type in which it is expressed. TRAF3 is a major regulator of the innate immune response. To perform its functions properly, TRAF3 is transcriptionally and epigenetically regulated. At the transcriptional level, TRAF3 expression has been associated with neurological and cardiovascular diseases including stroke, among other pathologies. Epigenetic modifications of TRAF3 have been observed at the histone and DNA levels. It has been observed that acetylation of TRAF3, as well as other NF-κβ target genes, is associated with cardiac hypertrophy. Furthermore, TRAF3 methylation has been associated with vascular recurrence after ischemic stroke in patients treated with clopidogrel. In this overview, we summarise the most interesting studies related to transcriptional and epigenetic regulation of TRAF3 focusing on those studies performed in neurological and cardiovascular diseases.
AB - Tumour necrosis factor receptor-associated factor 3 (TRAF3) is a member of the TRAF adaptor protein family, which exerts different effects on the cell depending on the receptor to which it binds and the cell type in which it is expressed. TRAF3 is a major regulator of the innate immune response. To perform its functions properly, TRAF3 is transcriptionally and epigenetically regulated. At the transcriptional level, TRAF3 expression has been associated with neurological and cardiovascular diseases including stroke, among other pathologies. Epigenetic modifications of TRAF3 have been observed at the histone and DNA levels. It has been observed that acetylation of TRAF3, as well as other NF-κβ target genes, is associated with cardiac hypertrophy. Furthermore, TRAF3 methylation has been associated with vascular recurrence after ischemic stroke in patients treated with clopidogrel. In this overview, we summarise the most interesting studies related to transcriptional and epigenetic regulation of TRAF3 focusing on those studies performed in neurological and cardiovascular diseases.
KW - Epigenetics
KW - EWAS
KW - Genetics
KW - Stroke
KW - TRAF3
UR - http://www.scopus.com/inward/record.url?scp=85037704889&partnerID=8YFLogxK
U2 - 10.1515/bmc-2017-0008
DO - 10.1515/bmc-2017-0008
M3 - Review article
C2 - 28753533
AN - SCOPUS:85037704889
SN - 1868-5021
VL - 8
SP - 197
EP - 202
JO - Biomolecular Concepts
JF - Biomolecular Concepts
IS - 3-4
ER -
