Role of TRAF3 in neurological and cardiovascular diseases: An overview of recent studies

Natalia Cullell, Elena Muiño, Caty Carrera, Nuria Torres, Jerzy Krupinski, Israel Fernandez-Cadenas*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

5 Citations (Scopus)

Abstract

Tumour necrosis factor receptor-associated factor 3 (TRAF3) is a member of the TRAF adaptor protein family, which exerts different effects on the cell depending on the receptor to which it binds and the cell type in which it is expressed. TRAF3 is a major regulator of the innate immune response. To perform its functions properly, TRAF3 is transcriptionally and epigenetically regulated. At the transcriptional level, TRAF3 expression has been associated with neurological and cardiovascular diseases including stroke, among other pathologies. Epigenetic modifications of TRAF3 have been observed at the histone and DNA levels. It has been observed that acetylation of TRAF3, as well as other NF-κβ target genes, is associated with cardiac hypertrophy. Furthermore, TRAF3 methylation has been associated with vascular recurrence after ischemic stroke in patients treated with clopidogrel. In this overview, we summarise the most interesting studies related to transcriptional and epigenetic regulation of TRAF3 focusing on those studies performed in neurological and cardiovascular diseases.

Original languageEnglish
Pages (from-to)197-202
Number of pages6
JournalBiomolecular Concepts
Volume8
Issue number3-4
DOIs
Publication statusPublished - Sept 2017

Keywords

  • Epigenetics
  • EWAS
  • Genetics
  • Stroke
  • TRAF3

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