Ribosomal proteins are targets for the NEDD8 pathway

Dimitris P. Xirodimas, Anders Sundqvist, Akihiro Nakamura, Linnan Shen, Catherine Botting, Ronald T. Hay

Research output: Contribution to journalArticlepeer-review

143 Citations (Scopus)

Abstract

Identification of the molecular targets for post-translational modifications is an important step for explaining the regulated pathways. The ubiquitin-like molecule NEDD8 is implicated in the regulation of cell proliferation, viability and development. By combining proteomics and in vivo NEDDylation assays, we identified a subset of ribosomal proteins as novel targets for the NEDD8 pathway. We further show that the lack of NEDDylation in cells causes ribosomal protein instability. Our studies identify a novel and specific role of the NEDD8 pathway in protecting a subset of ribosomal proteins from destabilization.

Original languageEnglish
Pages (from-to)280-286
Number of pages7
JournalEMBO Reports
Volume9
Issue number3
DOIs
Publication statusPublished - Mar 2008

Keywords

  • NEDD8
  • proteomics
  • proteasome
  • ribosomal proteins
  • UBIQUITIN
  • NUCLEOLUS
  • DYNAMICS
  • P53
  • CONJUGATION
  • BIOGENESIS
  • PROTEASE
  • COMPLEX
  • CULLIN
  • NEDP1

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