Reversible control of nanoparticle functionalization and physicochemical properties by dynamic covalent exchange

Flavio della Sala, Euan Robert Kay

Research output: Contribution to journalArticlepeer-review

47 Citations (Scopus)
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Abstract

Existing methods for the covalent functionalization of nanoparticles rely on kinetically controlled reactions, and largely lack the sophistication of the preeminent oligonucleotide-based noncovalent strategies. Here we report the application of dynamic covalent chemistry for the reversible modification of nanoparticle (NP) surface functionality, combining the benefits of non-biomolecular covalent chemistry with the favorable features of equilibrium processes. A homogeneous monolayer of nanoparticle-bound hydrazones can undergo quantitative dynamic covalent exchange. The pseudomolecular nature of the NP system allows for the in situ characterization of surface-bound species, and real-time tracking of the exchange reactions. Furthermore, dynamic covalent exchange offers a simple approach for reversibly switching—and subtly tuning—NP properties such as solvophilicity.
Original languageEnglish
Pages (from-to)4187–4191
JournalAngewandte Chemie International Edition
Volume54
Issue number14
Early online date14 Jan 2015
DOIs
Publication statusPublished - 27 Mar 2015

Keywords

  • Dynamic covalent chemistry
  • Gold nanoparticles
  • Hydrazones
  • Supramolecular chemistry

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