Reversible acylation of elastase by y-lactam analogues of B-lactam inhibitors

Nicholas James Westwood; TDW Claridge; PN Edwards; JC Schofield

Reversible acylation of elastase by y-lactam analogues of B-lactam inhibitors

Nicholas James Westwood, TDW Claridge, PN Edwards, JC Schofield

Research output: Contribution to journal › Article › peer-review

Abstract

The reaction of a monocyclic gamma-lactam with the serine protease elastase occurs via reversible formation of a hydrolytically labile acyl-enzyme complex; in contrast analogous beta-lactam inhibitors irreversibly react to form a relatively stable acyl-enzyme complex. (C) 1997 Elsevier Science Ltd.

Original language	English
Pages (from-to)	2973-2978
Number of pages	6
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	7
Publication status	Published - 2 Dec 1997

Keywords

HUMAN-LEUKOCYTE ELASTASE
STEREOSPECIFIC SYNTHESIS
ACID
ANTIBIOTICS
BINDING

Cite this

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title = "Reversible acylation of elastase by y-lactam analogues of B-lactam inhibitors",

abstract = "The reaction of a monocyclic gamma-lactam with the serine protease elastase occurs via reversible formation of a hydrolytically labile acyl-enzyme complex; in contrast analogous beta-lactam inhibitors irreversibly react to form a relatively stable acyl-enzyme complex. (C) 1997 Elsevier Science Ltd.",

keywords = "HUMAN-LEUKOCYTE ELASTASE, STEREOSPECIFIC SYNTHESIS, ACID, ANTIBIOTICS, BINDING",

author = "Westwood, \{Nicholas James\} and TDW Claridge and PN Edwards and JC Schofield",

year = "1997",

month = dec,

day = "2",

language = "English",

volume = "7",

pages = "2973--2978",

journal = "Bioorganic and Medicinal Chemistry Letters",

publisher = "Elsevier",

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TY - JOUR

T1 - Reversible acylation of elastase by y-lactam analogues of B-lactam inhibitors

AU - Westwood, Nicholas James

AU - Claridge, TDW

AU - Edwards, PN

AU - Schofield, JC

PY - 1997/12/2

Y1 - 1997/12/2

N2 - The reaction of a monocyclic gamma-lactam with the serine protease elastase occurs via reversible formation of a hydrolytically labile acyl-enzyme complex; in contrast analogous beta-lactam inhibitors irreversibly react to form a relatively stable acyl-enzyme complex. (C) 1997 Elsevier Science Ltd.

AB - The reaction of a monocyclic gamma-lactam with the serine protease elastase occurs via reversible formation of a hydrolytically labile acyl-enzyme complex; in contrast analogous beta-lactam inhibitors irreversibly react to form a relatively stable acyl-enzyme complex. (C) 1997 Elsevier Science Ltd.

KW - HUMAN-LEUKOCYTE ELASTASE

KW - STEREOSPECIFIC SYNTHESIS

KW - ACID

KW - ANTIBIOTICS

KW - BINDING

UR - https://www.scopus.com/pages/publications/0030687685

M3 - Article

VL - 7

SP - 2973

EP - 2978

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

ER -

Reversible acylation of elastase by y-lactam analogues of B-lactam inhibitors

Abstract

Keywords

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