Restriction fragment length polymorphism analysis of Mycobacterium tuberculosis isolated from patients with pulmonary tuberculosis in northern Tanzania

S. H. Gillespie; N. Kennedy; F. I. Ngowi; N. G. Fomukong; S. Al-Maamary; J. W. Dale

doi:10.1016/0035-9203(95)90571-5

Restriction fragment length polymorphism analysis of Mycobacterium tuberculosis isolated from patients with pulmonary tuberculosis in northern Tanzania

S. H. Gillespie^*, N. Kennedy, F. I. Ngowi, N. G. Fomukong, S. Al-Maamary, J. W. Dale

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

Isolates of Mycobacterium tuberculosis from 88 patients with pulmonary tuberculosis in northern Tanzania were subjected to IS6110 restriction fragment length polymorphism (RFLP) analysis. Of 88 isolates, 73 fell into 11 groups of which 9 contained 2-5 isolates. Of 2 large homology groupsone, group H (20 isolates), was isolated only from patients resident in the Kilimanjiro region, whereas 79% of isolates from other groups came from this region. A significant association (P=0.023) was found between another group, M (24 isolates) and isolation from patients of the Masai tribe. The data from this pilot study support the idea that IS6110 RFLP analysisprovides information which may be of value in the control of tuberculosis in Africa.

Original language	English
Pages (from-to)	335-338
Number of pages	4
Journal	Transactions of the Royal Society of Tropical Medicine and Hygiene
Volume	89
Issue number	3
DOIs	https://doi.org/10.1016/0035-9203(95)90571-5
Publication status	Published - 1 Jan 1995

Keywords

Mycobacterium tuberculosis
Restriction fragment length polymorphism analysis
Strain relationships
Tanzania
Tuberculosis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/0035-9203(95)90571-5

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Gillespie, S. H., Kennedy, N., Ngowi, F. I., Fomukong, N. G., Al-Maamary, S., & Dale, J. W. (1995). Restriction fragment length polymorphism analysis of Mycobacterium tuberculosis isolated from patients with pulmonary tuberculosis in northern Tanzania. Transactions of the Royal Society of Tropical Medicine and Hygiene, 89(3), 335-338. https://doi.org/10.1016/0035-9203(95)90571-5

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title = "Restriction fragment length polymorphism analysis of Mycobacterium tuberculosis isolated from patients with pulmonary tuberculosis in northern Tanzania",

abstract = "Isolates of Mycobacterium tuberculosis from 88 patients with pulmonary tuberculosis in northern Tanzania were subjected to IS6110 restriction fragment length polymorphism (RFLP) analysis. Of 88 isolates, 73 fell into 11 groups of which 9 contained 2-5 isolates. Of 2 large homology groupsone, group H (20 isolates), was isolated only from patients resident in the Kilimanjiro region, whereas 79% of isolates from other groups came from this region. A significant association (P=0.023) was found between another group, M (24 isolates) and isolation from patients of the Masai tribe. The data from this pilot study support the idea that IS6110 RFLP analysisprovides information which may be of value in the control of tuberculosis in Africa.",

keywords = "Mycobacterium tuberculosis, Restriction fragment length polymorphism analysis, Strain relationships, Tanzania, Tuberculosis",

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Gillespie, SH, Kennedy, N, Ngowi, FI, Fomukong, NG, Al-Maamary, S & Dale, JW 1995, 'Restriction fragment length polymorphism analysis of Mycobacterium tuberculosis isolated from patients with pulmonary tuberculosis in northern Tanzania', Transactions of the Royal Society of Tropical Medicine and Hygiene, vol. 89, no. 3, pp. 335-338. https://doi.org/10.1016/0035-9203(95)90571-5

Restriction fragment length polymorphism analysis of Mycobacterium tuberculosis isolated from patients with pulmonary tuberculosis in northern Tanzania. / Gillespie, S. H.; Kennedy, N.; Ngowi, F. I. et al.
In: Transactions of the Royal Society of Tropical Medicine and Hygiene, Vol. 89, No. 3, 01.01.1995, p. 335-338.

Research output: Contribution to journal › Article › peer-review

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T1 - Restriction fragment length polymorphism analysis of Mycobacterium tuberculosis isolated from patients with pulmonary tuberculosis in northern Tanzania

AU - Gillespie, S. H.

AU - Kennedy, N.

AU - Ngowi, F. I.

AU - Fomukong, N. G.

AU - Al-Maamary, S.

AU - Dale, J. W.

PY - 1995/1/1

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N2 - Isolates of Mycobacterium tuberculosis from 88 patients with pulmonary tuberculosis in northern Tanzania were subjected to IS6110 restriction fragment length polymorphism (RFLP) analysis. Of 88 isolates, 73 fell into 11 groups of which 9 contained 2-5 isolates. Of 2 large homology groupsone, group H (20 isolates), was isolated only from patients resident in the Kilimanjiro region, whereas 79% of isolates from other groups came from this region. A significant association (P=0.023) was found between another group, M (24 isolates) and isolation from patients of the Masai tribe. The data from this pilot study support the idea that IS6110 RFLP analysisprovides information which may be of value in the control of tuberculosis in Africa.

AB - Isolates of Mycobacterium tuberculosis from 88 patients with pulmonary tuberculosis in northern Tanzania were subjected to IS6110 restriction fragment length polymorphism (RFLP) analysis. Of 88 isolates, 73 fell into 11 groups of which 9 contained 2-5 isolates. Of 2 large homology groupsone, group H (20 isolates), was isolated only from patients resident in the Kilimanjiro region, whereas 79% of isolates from other groups came from this region. A significant association (P=0.023) was found between another group, M (24 isolates) and isolation from patients of the Masai tribe. The data from this pilot study support the idea that IS6110 RFLP analysisprovides information which may be of value in the control of tuberculosis in Africa.

KW - Mycobacterium tuberculosis

KW - Restriction fragment length polymorphism analysis

KW - Strain relationships

KW - Tanzania

KW - Tuberculosis

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Restriction fragment length polymorphism analysis of Mycobacterium tuberculosis isolated from patients with pulmonary tuberculosis in northern Tanzania

Abstract

Keywords

UN SDGs

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