Response-related deficits following unilateral lesions of the medial agranular cortex of the rat

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Abstract

Rats with lesions of the medial agranular frontal cortex (AGm) were tested for sensorimotor function. Spatial response bias and reaction time to lateralized visual targets were recorded in an automated test of visual reaction time. The same rats were also tested for somatosensory capacity and on a skilled reaching task. In all tasks, there was an ipsilateral response bias but no evidence of sensory neglect. In the visual reaction time task, initiation time was lengthened bilaterally. These deficits may parallel the effects on motor function after unilateral frontal cortical lesioning in primates. The results support the hypothesis that rat AGm contains a homologue of primate secondary motor cortex.

Original languageEnglish
Pages (from-to)567-78
Number of pages12
JournalBehavioral Neuroscience
Volume105
Issue number4
Publication statusPublished - Aug 1991

Keywords

  • FRONTAL EYE-FIELD
  • SUPPLEMENTARY MOTOR AREA
  • CORTICAL PROJECTIONS
  • AFFERENT CONNECTIONS
  • DOPAMINE DEPLETION
  • PREFRONTAL CORTEX
  • ROSTRAL PORTION
  • NEGLECT
  • ATTENTION
  • ORGANIZATION

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