Abstract
Replacement of dichloromethane as the bulk medium within chromatographic purification has been evaluated with a broad range of molecules containing functionality common within Medicinal Chemistry programmes. Analysis of the data set has generated a set of general guidelines to assist in the selection of alternative solvents for CH2Cl2 as the bulk media in these ubiquitously employed processes.
| Original language | English |
|---|---|
| Pages (from-to) | 3016-3019 |
| Number of pages | 4 |
| Journal | Green Chemistry |
| Volume | 14 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - 2012 |
Keywords
- green chemistry
- purification
- alternative solvents
- chromatography
- replacement
- dichloromethane
- chromatographic purification
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