Replacement of dichloromethane within chromatographic purification

Donna Stephanie MacMillan, Jane Murray, Helen F. Sneddon, Craig Jamieson, Allan Watson

Research output: Contribution to journalArticlepeer-review

43 Citations (Scopus)


Replacement of dichloromethane as the bulk medium within chromatographic purification has been evaluated with a broad range of molecules containing functionality common within Medicinal Chemistry programmes. Analysis of the data set has generated a set of general guidelines to assist in the selection of alternative solvents for CH2Cl2 as the bulk media in these ubiquitously employed processes.
Original languageEnglish
Pages (from-to)3016-3019
Number of pages4
JournalGreen Chemistry
Issue number11
Publication statusPublished - 2012


  • green chemistry
  • purification
  • alternative solvents
  • chromatography
  • replacement
  • dichloromethane
  • chromatographic purification


Dive into the research topics of 'Replacement of dichloromethane within chromatographic purification'. Together they form a unique fingerprint.

Cite this