Regulation of exosome release from mammary epithelial and breast cancer cells - a new regulatory pathway

Andrew Riches, Elaine Campbell, Eva Borger, Simon Powis

Research output: Contribution to journalArticlepeer-review

139 Citations (Scopus)

Abstract

Exosomes are small 50-100nm sized extracellular vesicles released from normal and tumour cells and are a source of a new intercellular communication pathway. Tumour exosomes promote tumour growth and progression. What regulates the release and homoeostatic levels of exosomes, in cancer, in body fluids remains undefined.
Original languageEnglish
Pages (from-to)1025-34
Number of pages10
JournalEuropean Journal of Cancer
Volume50
Issue number5
Early online date24 Jan 2014
DOIs
Publication statusPublished - Mar 2014

Keywords

  • Blotting, Western
  • Breast Neoplasms
  • Cell Line, Tumor
  • Cells, Cultured
  • Epithelial Cells
  • Exosomes
  • Extracellular Space
  • Female
  • Fluorescent Dyes
  • Humans
  • Mammary Glands, Human
  • Microscopy, Confocal
  • Organic Chemicals
  • Signal Transduction
  • Time Factors

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