Abstract
The NBS bromination of 1,4-dimethoxy-2,3-dimethylbenzene has been examined under a variety of conditions in both 1,1,1-trichloroethane and benzotrifluoride. Four different bromination products have been isolated including the previously unknown 1-bromo-4-bromomethyl-2,5-dimethoxy-3-methylbenzene whose single crystal X-ray structure is presented. The synthetically useful 2,3-bis(bromomethyl)-1,4-dimethoxybenzene is readily prepared using either solvent and it has been converted into new sulfur-containing quinone derivatives
Original language | English |
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Pages (from-to) | 1563-1566 |
Number of pages | 4 |
Journal | Tetrahedron Letters |
Volume | 57 |
Issue number | 14 |
Early online date | 27 Feb 2016 |
DOIs | |
Publication status | Published - 11 Mar 2016 |
Keywords
- Bromination
- Benzotrifluoride
- Solvent effects
- X-ray structures
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Regioselective bromination of 1,4-dimethoxy-2,3-dimethylbenzene and conversion into sulfur-functionalised benzoquinones (dataset)
Aitken, R. A. (Creator), Jethwa, S. J. (Creator), Richardson, N. V. (Creator) & Slawin, A. M. Z. (Creator), Cambridge Crystallographic Data Centre, 2015
https://dx.doi.org/10.5517/cc1kg427
Dataset