TY - JOUR
T1 - Recent progress in antiretrovirals - lessons from resistance
AU - Adamson, Catherine Sarah
AU - Freed, E.O.
PY - 2008/5
Y1 - 2008/5
N2 - Recent failures in efforts to develop an effective vaccine against HIV-1 infection have emphasized the importance of antiretroviral therapy in treating HIV-1-infected patients. Thus far, inhibitors of two viral enzymes, reverse transcriptase and protease, have had a profoundly positive impact on the survival of HIV-1-infected patients. However, new inhibitors that act at diverse steps in the viral replication cycle are urgently needed because of the development of resistance to currently available antiretrovirals. This review summarizes recent progress in antiretroviral drug discovery and development by specifically focusing on novel inhibitors of three phases of replication: viral entry, integration of the viral DNA into the host cell genome and virus particle maturation.
AB - Recent failures in efforts to develop an effective vaccine against HIV-1 infection have emphasized the importance of antiretroviral therapy in treating HIV-1-infected patients. Thus far, inhibitors of two viral enzymes, reverse transcriptase and protease, have had a profoundly positive impact on the survival of HIV-1-infected patients. However, new inhibitors that act at diverse steps in the viral replication cycle are urgently needed because of the development of resistance to currently available antiretrovirals. This review summarizes recent progress in antiretroviral drug discovery and development by specifically focusing on novel inhibitors of three phases of replication: viral entry, integration of the viral DNA into the host cell genome and virus particle maturation.
UR - http://www.scopus.com/inward/record.url?scp=43049180280&partnerID=8YFLogxK
UR - http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T64-4S9R8D4-1&_user=1026342&_coverDate=05%2F31%2F2008&_rdoc=10&_fmt=high&_orig=browse&_srch=doc-info(%23toc%235020%232008%23999869990%23689052%23FLA%23display%23Volume)&_cdi=5020&_sort=d&_docanchor=&_ct=15&_acct=C000050565&_version=1&_urlVersion=0&_userid=1026342&md5=24b8e50392f17b4dd62b3f1740c3429e
U2 - doi:10.1016/j.drudis.2008.02.003
DO - doi:10.1016/j.drudis.2008.02.003
M3 - Article
VL - 13
SP - 424
EP - 432
JO - Drug Discovery Today
JF - Drug Discovery Today
IS - 9-10
ER -