Rapid diagnosis of whooping cough using monoclonal antibody

P. C. Boreland, S. H. Gillespie, L. A.E. Ashworth

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


A counterimmunoelectrophoresis (CIE) method for antigen detection using monoclonal antibody was assessed for its ability to aid in the rapid diagnosis of Bordetella pertussis in 59 patients. A positive diagnosis from a combination of results from tests of serum and urine was obtained in 51 (87%) of cases. For sera, CIE had a sensitivity of 85% and a specificity of 94%; for urine samples the sensitivity was 81% and a specificity of 100%. Antigen detection by CIE is simple to perform and yields results on the same day, thus allowing treatment to begin at an early stage.

Original languageEnglish
Pages (from-to)573-575
Number of pages3
JournalJournal of Clinical Pathology
Issue number5
Publication statusPublished - 1 Jan 1988


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