Rapid asymmetric transfer hydroformylation (ATHF) of disubstituted alkenes using paraformaldehyde as a syngas surrogate

José Antonio Fuentes García, Rachael Pittaway, Matt Clarke*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)
1 Downloads (Pure)

Abstract

As an alternative to conventional asymmetric hydroformylation (AHF), Asymmetric Transfer Hydroformylation (ATHF) using formaldehyde as a surrogate for syngas is reported. A catalyst derived from commercially available [Rh(acac)(CO)2] and Ph-BPE stands out in terms of both activity and enantioselectivity. Remarkably, not only are high selectivities achievable, the reactions are very simple to carry out, and can give higher enantioselectivity (up to 96% e.e.) and/or turnover frequencies than those that are achievable using the same catalyst (or other leading catalysts) using typical conditions for AHF.

Original languageEnglish
Pages (from-to)10645-10649
JournalChemistry - A European Journal
Volume21
Issue number30
Early online date25 Jun 2015
DOIs
Publication statusPublished - 14 Jul 2015

Keywords

  • Enantioselective Catalysis
  • Microwave
  • Carbinylation
  • Hydroformylation
  • Formaldehyde

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