Abstract
Percutaneous coronary intervention for the treatment of coronary artery
disease is most commonly performed in the UK through the radial artery,
as this is safer than the femoral approach. However, despite
improvements in technology and techniques, complications can occur. The
most common complication, arterial spasm, can cause intense pain and, in
some cases, procedural failure. The incidence of spasm is dependent on
several variables, including operator experience, artery size, and
equipment used. An anti-spasmolytic cocktail can be applied to reduce
spasm, which usually includes an exogenous nitric oxide (NO) donor
(glyceryl trinitrate). NO is an endogenous local vasodilator and
therefore is a potential target for anti-spasm intervention. However,
systemic administration can result in unwanted side-effects, such as
hypotension. A method that adopts local delivery of NO might be
advantageous. This review article describes the mechanisms involved in
radial artery spasm, discusses the advantages and disadvantages of
current strategies to reduce spasm, and highlight the potential of
NO-loaded nanoporous materials for use in this setting.
Original language | English |
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Pages (from-to) | 26-34 |
Journal | World Journal of Cardiology |
Volume | 12 |
Issue number | 1 |
DOIs | |
Publication status | Published - 26 Jan 2020 |
Keywords
- Radial artery
- Cannulation
- Spasm
- Nitric oxide
- Vasodilation
- Nanoporous material