Questions in the chemical enzymology of MAO

Rona R. Ramsay; Alen Albreht

doi:10.3390/chemistry3030069

Questions in the chemical enzymology of MAO

Rona R. Ramsay^*
, Alen Albreht

^*Corresponding author for this work

School of Biology

Research output: Contribution to journal › Review article › peer-review

Abstract

We have structure, a wealth of kinetic data, thousands of chemical ligands, and clinical 8 information for the effects of a range of drugs on monoamine oxidase activity in vivo. We have 9 comparative information from various species and mutations on kinetics, and effects of inhibition. 10 Yet there are what seem like simple questions still to be answered. This article presents a brief sum-11 mary of existing experimental evidence the background and poses questions that remain intriguing 12 for chemists and biochemists researching the chemical enzymology of and drug design for mono-13 amine oxidases (FAD-containing EC 4.1.3.4).

Original language	English
Pages (from-to)	959-978
Journal	Chemistry
Volume	3
Issue number	3
DOIs	https://doi.org/10.3390/chemistry3030069
Publication status	Published - 31 Aug 2021

Keywords

Chemical mechanism
Kinetic mechanism
Oxidation
Protein flexibiity
Cysteine modification
Reversible/irreversible inhibition
Molecular dynmaics
Simulation

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@article{26b3534bc8f54c9f990e1daafe39681d,

title = "Questions in the chemical enzymology of MAO",

abstract = "We have structure, a wealth of kinetic data, thousands of chemical ligands, and clinical 8 information for the effects of a range of drugs on monoamine oxidase activity in vivo. We have 9 comparative information from various species and mutations on kinetics, and effects of inhibition. 10 Yet there are what seem like simple questions still to be answered. This article presents a brief sum-11 mary of existing experimental evidence the background and poses questions that remain intriguing 12 for chemists and biochemists researching the chemical enzymology of and drug design for mono-13 amine oxidases (FAD-containing EC 4.1.3.4).",

keywords = "Chemical mechanism, Kinetic mechanism, Oxidation, Protein flexibiity, Cysteine modification, Reversible/irreversible inhibition, Molecular dynmaics, Simulation",

author = "Ramsay, \{Rona R.\} and Alen Albreht",

note = "A.A. is supported by the Slovenian Research Agency (Research Program P1-0005). ",

year = "2021",

month = aug,

day = "31",

doi = "10.3390/chemistry3030069",

language = "English",

volume = "3",

pages = "959--978",

journal = "Chemistry",

issn = "2624-8549",

publisher = "MDPI",

number = "3",

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TY - JOUR

T1 - Questions in the chemical enzymology of MAO

AU - Ramsay, Rona R.

AU - Albreht, Alen

N1 - A.A. is supported by the Slovenian Research Agency (Research Program P1-0005).

PY - 2021/8/31

Y1 - 2021/8/31

N2 - We have structure, a wealth of kinetic data, thousands of chemical ligands, and clinical 8 information for the effects of a range of drugs on monoamine oxidase activity in vivo. We have 9 comparative information from various species and mutations on kinetics, and effects of inhibition. 10 Yet there are what seem like simple questions still to be answered. This article presents a brief sum-11 mary of existing experimental evidence the background and poses questions that remain intriguing 12 for chemists and biochemists researching the chemical enzymology of and drug design for mono-13 amine oxidases (FAD-containing EC 4.1.3.4).

AB - We have structure, a wealth of kinetic data, thousands of chemical ligands, and clinical 8 information for the effects of a range of drugs on monoamine oxidase activity in vivo. We have 9 comparative information from various species and mutations on kinetics, and effects of inhibition. 10 Yet there are what seem like simple questions still to be answered. This article presents a brief sum-11 mary of existing experimental evidence the background and poses questions that remain intriguing 12 for chemists and biochemists researching the chemical enzymology of and drug design for mono-13 amine oxidases (FAD-containing EC 4.1.3.4).

KW - Chemical mechanism

KW - Kinetic mechanism

KW - Oxidation

KW - Protein flexibiity

KW - Cysteine modification

KW - Reversible/irreversible inhibition

KW - Molecular dynmaics

KW - Simulation

U2 - 10.3390/chemistry3030069

DO - 10.3390/chemistry3030069

M3 - Review article

SN - 2624-8549

VL - 3

SP - 959

EP - 978

JO - Chemistry

JF - Chemistry

IS - 3

ER -

Questions in the chemical enzymology of MAO

Abstract

Keywords

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