Abstract
We have structure, a wealth of kinetic data, thousands of chemical ligands, and clinical 8 information for the effects of a range of drugs on monoamine oxidase activity in vivo. We have 9 comparative information from various species and mutations on kinetics, and effects of inhibition. 10 Yet there are what seem like simple questions still to be answered. This article presents a brief sum-11 mary of existing experimental evidence the background and poses questions that remain intriguing 12 for chemists and biochemists researching the chemical enzymology of and drug design for mono-13 amine oxidases (FAD-containing EC 4.1.3.4).
Original language | English |
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Pages (from-to) | 959-978 |
Journal | Chemistry |
Volume | 3 |
Issue number | 3 |
DOIs | |
Publication status | Published - 31 Aug 2021 |
Keywords
- Chemical mechanism
- Kinetic mechanism
- Oxidation
- Protein flexibiity
- Cysteine modification
- Reversible/irreversible inhibition
- Molecular dynmaics
- Simulation