Questions in the chemical enzymology of MAO

Rona R. Ramsay*, Alen Albreht

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

We have structure, a wealth of kinetic data, thousands of chemical ligands, and clinical 8 information for the effects of a range of drugs on monoamine oxidase activity in vivo. We have 9 comparative information from various species and mutations on kinetics, and effects of inhibition. 10 Yet there are what seem like simple questions still to be answered. This article presents a brief sum-11 mary of existing experimental evidence the background and poses questions that remain intriguing 12 for chemists and biochemists researching the chemical enzymology of and drug design for mono-13 amine oxidases (FAD-containing EC 4.1.3.4).
Original languageEnglish
Pages (from-to)959-978
JournalChemistry
Volume3
Issue number3
DOIs
Publication statusPublished - 31 Aug 2021

Keywords

  • Chemical mechanism
  • Kinetic mechanism
  • Oxidation
  • Protein flexibiity
  • Cysteine modification
  • Reversible/irreversible inhibition
  • Molecular dynmaics
  • Simulation

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