Quantitative host resistance drives the evolution of increased virulence in an emerging pathogen

Daisy Elizabeth Gates, John Joseph Valletta, Camille Bonneaud, Mario Recker*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

Emergent infectious diseases can have a devastating impact on host populations. The high selective pressures on both the hosts and the pathogens frequently lead to rapid adaptations not only in pathogen virulence but also host resistance following an initial outbreak. However, it is often unclear whether hosts will evolve to avoid infection‐associated fitness costs by preventing the establishment of infection (here referred to as qualitative resistance ) or by limiting its deleterious effects through immune functioning (here referred to as quantitative resistance ). Equally, the evolutionary repercussions these different resistance mechanisms have for the pathogen are often unknown. Here, we investigate the co‐evolutionary dynamics of pathogen virulence and host resistance following the epizootic outbreak of the highly pathogenic bacterium Mycoplasma gallisepticum in North American house finches (Haemorhous mexicanus ). Using an evolutionary modelling approach and with a specific emphasis on the evolved resistance trait, we demonstrate that the rapid increase in the frequency of resistant birds following the outbreak is indicative of strong selection pressure to reduce infection‐associated mortality. This, in turn, created the ecological conditions that selected for increased bacterial virulence. Our results thus suggest that quantitative host resistance was the key factor underlying the evolutionary interactions in this natural host–pathogen system.
Original languageEnglish
Pages (from-to)1704-1714
Number of pages11
JournalJournal of Evolutionary Biology
Volume31
Issue number11
Early online date6 Sept 2018
DOIs
Publication statusPublished - 2 Nov 2018

Keywords

  • House finches
  • Mathematical model
  • Mycoplasma gallisepticum
  • Qualitative resistance
  • Quantitative resistance
  • Virulence evolution

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