Quantitative compression optical coherence elastography as an inverse elasticity problem

Li Dong, Philip Wijesinghe, James T. Dantuono, David D. Sampson, Peter R.T. Munro, Brendan F. Kennedy, Assad A. Oberai

Research output: Contribution to journalArticlepeer-review

42 Citations (Scopus)


Quantitative elasticity imaging seeks to retrieve spatial maps of elastic moduli of tissue. Unlike strain, which is commonly imaged in compression elastography, elastic moduli are intrinsic properties of tissue, and therefore, this approach reconstructs images that are largely operator and system independent, enabling objective, longitudinal, and multisite diagnoses. Recently, novel quantitative elasticity imaging approaches to compression elastography have been developed. These methods use a calibration layer with known mechanical properties to sense the stress at the tissue surface, which combined with strain, is used to estimate the tissue's elastic moduli by assuming homogeneity in the stress field. However, this assumption is violated in mechanically heterogeneous samples. We present a more general approach to quantitative elasticity imaging that overcomes this limitation through an efficient iterative solution of the inverse elasticity problem using adjoint elasticity equations. We present solutions for linear elastic, isotropic, and incompressible solids; however, this method can be employed for more complex mechanical models. We retrieve the spatial distribution of shear modulus for a tissue-simulating phantom and a tissue sample. This is the first time, to our knowledge, that the iterative solution of the inverse elasticity problem has been implemented on experimentally acquired compression optical coherence elastography data.
Original languageEnglish
Article number7366542
Number of pages11
JournalIEEE Journal of Selected Topics in Quantum Electronics
Issue number3
Early online date25 Dec 2015
Publication statusPublished - May 2016


  • Compression optical coherence elastography
  • Inverse elasticity problems
  • Optical coherence tomography
  • Quantitative elasticity imaging


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