Quantification of tumour budding, lymphatic vessel density and invasion through image analysis in colorectal cancer

Peter David Caie; Arran K Turnbull; Susan M Farrington; Anca Oniscu; David J Harrison

doi:10.1186/1479-5876-12-156

Quantification of tumour budding, lymphatic vessel density and invasion through image analysis in colorectal cancer

Peter David Caie, Arran K Turnbull, Susan M Farrington, Anca Oniscu, David J Harrison

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Tumour budding (TB), lymphatic vessel density (LVD) and lymphatic vessel invasion (LVI) have shown promise as prognostic factors in colorectal cancer (CRC) but reproducibility using conventional histopathology is challenging. We demonstrate image analysis methodology to quantify the histopathological features which could permit standardisation across institutes and aid risk stratification of Dukes B patients.

Original language	English
Article number	156
Number of pages	22
Journal	Journal of Translational Medicine
Volume	12
Issue number	1
DOIs	https://doi.org/10.1186/1479-5876-12-156
Publication status	Published - 1 Jun 2014

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Image analysis
Lymphatic vessel density
Lymphatic vessel invasion
Tumour budding
Colorectal
Prognosis
Digital pathology

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10.1186/1479-5876-12-156

caie2014jtranslationalmed156
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
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Cite this

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title = "Quantification of tumour budding, lymphatic vessel density and invasion through image analysis in colorectal cancer",

abstract = "Tumour budding (TB), lymphatic vessel density (LVD) and lymphatic vessel invasion (LVI) have shown promise as prognostic factors in colorectal cancer (CRC) but reproducibility using conventional histopathology is challenging. We demonstrate image analysis methodology to quantify the histopathological features which could permit standardisation across institutes and aid risk stratification of Dukes B patients.",

keywords = "Image analysis, Lymphatic vessel density, Lymphatic vessel invasion, Tumour budding, Colorectal, Prognosis, Digital pathology",

author = "Caie, \{Peter David\} and Turnbull, \{Arran K\} and Farrington, \{Susan M\} and Anca Oniscu and Harrison, \{David J\}",

note = "Funding: University of St Andrews and NHS Lothian.",

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doi = "10.1186/1479-5876-12-156",

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AU - Caie, Peter David

AU - Turnbull, Arran K

AU - Farrington, Susan M

AU - Oniscu, Anca

AU - Harrison, David J

N1 - Funding: University of St Andrews and NHS Lothian.

PY - 2014/6/1

Y1 - 2014/6/1

N2 - Tumour budding (TB), lymphatic vessel density (LVD) and lymphatic vessel invasion (LVI) have shown promise as prognostic factors in colorectal cancer (CRC) but reproducibility using conventional histopathology is challenging. We demonstrate image analysis methodology to quantify the histopathological features which could permit standardisation across institutes and aid risk stratification of Dukes B patients.

AB - Tumour budding (TB), lymphatic vessel density (LVD) and lymphatic vessel invasion (LVI) have shown promise as prognostic factors in colorectal cancer (CRC) but reproducibility using conventional histopathology is challenging. We demonstrate image analysis methodology to quantify the histopathological features which could permit standardisation across institutes and aid risk stratification of Dukes B patients.

KW - Image analysis

KW - Lymphatic vessel density

KW - Lymphatic vessel invasion

KW - Tumour budding

KW - Colorectal

KW - Prognosis

KW - Digital pathology

UR - https://www.scopus.com/pages/publications/84904393656

U2 - 10.1186/1479-5876-12-156

DO - 10.1186/1479-5876-12-156

M3 - Article

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SN - 1479-5876

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JO - Journal of Translational Medicine

JF - Journal of Translational Medicine

IS - 1

M1 - 156

ER -

Quantification of tumour budding, lymphatic vessel density and invasion through image analysis in colorectal cancer

Abstract

UN SDGs

Keywords

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