Quantification of tumour budding, lymphatic vessel density and invasion through image analysis in colorectal cancer

Peter David Caie, Arran K Turnbull, Susan M Farrington, Anca Oniscu, David J Harrison

Research output: Contribution to journalArticlepeer-review

42 Citations (Scopus)
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Abstract

Tumour budding (TB), lymphatic vessel density (LVD) and lymphatic vessel invasion (LVI) have shown promise as prognostic factors in colorectal cancer (CRC) but reproducibility using conventional histopathology is challenging. We demonstrate image analysis methodology to quantify the histopathological features which could permit standardisation across institutes and aid risk stratification of Dukes B patients.
Original languageEnglish
Article number156
Number of pages22
JournalJournal of Translational Medicine
Volume12
Issue number1
DOIs
Publication statusPublished - 1 Jun 2014

Keywords

  • Image analysis
  • Lymphatic vessel density
  • Lymphatic vessel invasion
  • Tumour budding
  • Colorectal
  • Prognosis
  • Digital pathology

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