Quantification of lignans in food using isotope dilution gas chromatography/mass spectrometry

J L Penalvo, K M Haajanen, N Botting, H Adlercreutz

Research output: Contribution to journalArticlepeer-review

168 Citations (Scopus)

Abstract

The optimization and validation of a protocol for the quantification of six dietary lignans, i.e., secoisolariciresinol, matairesinol, lariciresinol, pinoresinol, medioresinol, and syringaresinol, in food are presented. The method incorporates isotope dilution to ensure correct accuracy and precision, introducing the utilization of individual stable C-13(3)-labeled lignans. To demonstrate the potential of this new method, preliminary results of the levels of dietary lignans in selected foods are presented. It is concluded that the method fulfils the reliability criteria and can be applied to the analysis of the most common lignans in human food, being an essential asset to establish the intake of lignans in a determined population and their relation with disease prevention.

Original languageEnglish
Pages (from-to)9342-9347
Number of pages6
JournalJournal of Agricultural and Food Chemistry
Volume53
DOIs
Publication statusPublished - 30 Nov 2005

Keywords

  • lignans
  • isotope dilution
  • food
  • phytoestrogens
  • secoisolariciresinol
  • matairesinol
  • lariciresinol
  • pinoresinol
  • medioresinol
  • syringaresinol
  • TANDEM MASS-SPECTROMETRY
  • PLANT LIGNANS
  • MAMMALIAN LIGNANS
  • SECOISOLARICIRESINOL
  • MATAIRESINOL
  • PINORESINOL
  • FLAXSEED
  • URINE
  • IDENTIFICATION
  • ENTEROLACTONE

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