Abstract
This paper describes a general procedure for the two-step purification of recombinant proteins as antibody-antigen complexes in which there is no uncomplexed antibody or antigen. In this way, immune complexes containing the p17, p27, vpr and vpx proteins of simian immunodeficiency virus (SIV) have been purified. Antibody-antigen complexes are more immunogenic than antigen when administered either alone or with alum. The significance of the work is that this general method could be modified for the manufacture of immune complexes for incorporation into multivalent vaccines.
| Original language | English |
|---|---|
| Pages (from-to) | 351-8 |
| Number of pages | 8 |
| Journal | Vaccine |
| Volume | 12 |
| Issue number | 4 |
| Publication status | Published - Mar 1994 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- SIV
- VACCINE
- SMAA COMPLEXES
- ANTIBODY-ANTIGEN COMPLEXES
- MONOCLONAL-ANTIBODIES
- ACTIVATION
- ADSORBENT
- CELLS
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