"Pure by NMR"?

Timothy D. W. Claridge, Stephen G. Davies, Mario E. C. Polywka, Paul M. Roberts, Angela J. Russell, Edward D. Savory, Andrew D. Smith

Research output: Contribution to journalArticlepeer-review

38 Citations (Scopus)

Abstract

Integration of a C-13-H-1 satellite peak of a given C-12-H-1 parent resonance within a quantitative H-1 NMR spectrum and comparison to the minor component represents a simple protocol for the accurate determination of diastereoisomeric ratios of up to 1000:1 (i.e., 99.8% de).

Original languageEnglish
Pages (from-to)5433-5436
Number of pages4
JournalOrganic Letters
Volume10
Issue number23
DOIs
Publication statusPublished - 4 Dec 2008

Keywords

  • NUCLEAR-MAGNETIC-RESONANCE
  • QUANTITATIVE-ANALYSIS
  • SPECTROSCOPY
  • SPECTROMETRY
  • H-1-NMR
  • PURITY
  • POLYDIMETHYLSILOXANE
  • QUANTIFICATION
  • VALIDATION
  • CHEMICALS

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