"Pure by NMR"?

Timothy D. W. Claridge; Stephen G. Davies; Mario E. C. Polywka; Paul M. Roberts; Angela J. Russell; Edward D. Savory; Andrew D. Smith

doi:10.1021/ol802211p

"Pure by NMR"?

Timothy D. W. Claridge, Stephen G. Davies, Mario E. C. Polywka, Paul M. Roberts, Angela J. Russell, Edward D. Savory, Andrew D. Smith

Research output: Contribution to journal › Article › peer-review

Abstract

Integration of a C-13-H-1 satellite peak of a given C-12-H-1 parent resonance within a quantitative H-1 NMR spectrum and comparison to the minor component represents a simple protocol for the accurate determination of diastereoisomeric ratios of up to 1000:1 (i.e., 99.8% de).

Original language	English
Pages (from-to)	5433-5436
Number of pages	4
Journal	Organic Letters
Volume	10
Issue number	23
DOIs	https://doi.org/10.1021/ol802211p
Publication status	Published - 4 Dec 2008

Keywords

NUCLEAR-MAGNETIC-RESONANCE
QUANTITATIVE-ANALYSIS
SPECTROSCOPY
SPECTROMETRY
H-1-NMR
PURITY
POLYDIMETHYLSILOXANE
QUANTIFICATION
VALIDATION
CHEMICALS

Access to Document

10.1021/ol802211p

Cite this

@article{11174143057647369c2d38ebdfa67dc4,

title = "{"}Pure by NMR{"}?",

abstract = "Integration of a C-13-H-1 satellite peak of a given C-12-H-1 parent resonance within a quantitative H-1 NMR spectrum and comparison to the minor component represents a simple protocol for the accurate determination of diastereoisomeric ratios of up to 1000:1 (i.e., 99.8% de).",

keywords = "NUCLEAR-MAGNETIC-RESONANCE, QUANTITATIVE-ANALYSIS, SPECTROSCOPY, SPECTROMETRY, H-1-NMR, PURITY, POLYDIMETHYLSILOXANE, QUANTIFICATION, VALIDATION, CHEMICALS",

author = "Claridge, {Timothy D. W.} and Davies, {Stephen G.} and Polywka, {Mario E. C.} and Roberts, {Paul M.} and Russell, {Angela J.} and Savory, {Edward D.} and Smith, {Andrew D.}",

year = "2008",

month = dec,

day = "4",

doi = "10.1021/ol802211p",

language = "English",

volume = "10",

pages = "5433--5436",

journal = "Organic Letters",

issn = "1523-7060",