Protein-protein interactions leading to recruitment of the host DNA sliding clamp by the hyperthermophilic Sulfolobus islandicus rod- shaped virus 2

A.F. Gardner, S.D. Bell, M.F. White, D. Prangishvili, M. Krupovic

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)
4 Downloads (Pure)

Abstract

Viruses infecting hyperthermophilic archaea typically do not encode DNA polymerases, raising questions regarding their genome replication. Here, using a yeast two-hybrid approach, we have assessed interactions between proteins of Sulfolobus islandicus rod-shaped virus 2 (SIRV2) and the host-encoded proliferating cell nuclear antigen (PCNA), a key DNA replication protein in archaea. Five SIRV2 proteins were found to interact with PCNA, providing insights into the recruitment of host replisome for viral DNA replication.

Original languageEnglish
Pages (from-to)7105-7108
Number of pages4
JournalJournal of Virology
Volume88
Issue number12
DOIs
Publication statusPublished - 1 Jun 2014

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