Projects per year
Abstract
The foetal plasma protein α-fetoprotein (AFP) harbours a high-affinity zinc binding site that is likely involved in transport and delivery of essential zinc during foetal development. Based on a recent electron microscopy structure of AFP and aided by biophysical studies on an AFP-derived peptide, we present a refined 5-coordinate model for this site.
Original language | English |
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Pages (from-to) | 2099-2102 |
Number of pages | 4 |
Journal | Chemical Communications |
Volume | 61 |
Issue number | 10 |
DOIs | |
Publication status | Published - 4 Feb 2025 |
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Dive into the research topics of 'Properties of the major Zn2+-binding site of human alpha-fetoprotein, a potential foetal plasma zinc carrier'. Together they form a unique fingerprint.Projects
- 3 Finished
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A Quantitive framework linking: A Quantitive framework linking extracellular zinc speciation and cell uptake
Stewart, A. J. (PI)
4/09/17 → 3/09/20
Project: Standard
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Dynamics of Circulatory Zinc Handling: The Dynamics of Circulatory Zinc Handling and Transport
Stewart, A. J. (PI)
9/04/12 → 8/04/15
Project: Standard