Properties of the major Zn2+-binding site of human alpha-fetoprotein, a potential foetal plasma zinc carrier

Jin Lu, Stephen J. Hierons, Swati Arya, Remi Fritzen, Sirilata Polepalli, Siavash Khazaipoul, Alan J. Stewart*, Claudia A. Blindauer*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

The foetal plasma protein α-fetoprotein (AFP) harbours a high-affinity zinc binding site that is likely involved in transport and delivery of essential zinc during foetal development. Based on a recent electron microscopy structure of AFP and aided by biophysical studies on an AFP-derived peptide, we present a refined 5-coordinate model for this site.
Original languageEnglish
Pages (from-to)2099-2102
Number of pages4
JournalChemical Communications
Volume61
Issue number10
DOIs
Publication statusPublished - 4 Feb 2025

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