Probing the limits of selectivity in a recognition-mediated reaction network embedded within a dynamic covalent library

Tamara Kosikova; Harry Mackenzie; Douglas Philp

doi:10.1002/chem.201503740

Probing the limits of selectivity in a recognition-mediated reaction network embedded within a dynamic covalent library

Tamara Kosikova, Harry Mackenzie, Douglas Philp

Research output: Contribution to journal › Article › peer-review

Abstract

Two recognition-mediated reaction processes operating through a reactive binary complex drive resolution of a 24-component dynamic covalent library, assembled from individual aldehydes and nucleophiles. The effectiveness of the library resolution and selective amplification of one recognition-enabled species over another is limited by the difference in the rates of the recognition-mediated reactive processes and strength of the recognition processes employed in the dynamic system.

Original language	English
Pages (from-to)	1831–1839
Journal	Chemistry - A European Journal
Volume	22
Issue number	5
DOIs	https://doi.org/10.1002/chem.201503740
Publication status	Published - 26 Jan 2016

Keywords

Combinatorial chemistry
Cycloaddition reaction
Kinetics
Molecular recognition
NMR spectroscop

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10.1002/chem.201503740

AB_DCL_TK_Final_ChemEurJ
© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. This work is made available online in accordance with the publisher’s policies. This is the author created, accepted version manuscript following peer review and may differ slightly from the final published version. The final published version of this work is available at https://dx.doi.org/10.1002/chem.201503740
Accepted author manuscript, 3.26 MB

Data Underpinning - Probing the limits of selectivity in a recognition-mediated reaction network embedded within a dynamic covalent library
Kosikova, T. (Creator), Mackenzie, H. (Creator) & Philp, D. (Creator), University of St Andrews, 20 Sept 2016
DOI: 10.17630/2a427a7e-d025-492e-9301-377e18459060
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AU - Philp, Douglas

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KW - Cycloaddition reaction

KW - Kinetics

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KW - NMR spectroscop

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Probing the limits of selectivity in a recognition-mediated reaction network embedded within a dynamic covalent library

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Data Underpinning - Probing the limits of selectivity in a recognition-mediated reaction network embedded within a dynamic covalent library

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