Probing Structural Effects on Replication Efficiency through Comparative Analyses of Families of Potential Self-Replicators

E Kassianidis, R J Pearson, Douglas Philp

Research output: Contribution to journalArticlepeer-review

28 Citations (Scopus)

Abstract

A formidable synthetic apparatus for the creation of nanoscale molecular structures and supramolecular assemblies through molecular structures can potentially be created from systems that are capable of parallel automultiplication (self-replication). In order to achieve this goal, a detailed understanding of the relationship between molecular structure and replication efficiency is necessary. Diastereoisomeric templates that are capable of specific and simultaneous autocatalysis have been synthesised. A systematic experimental and theoretical evaluation of their behaviour and that of structurally-related systems reveals the key determinants that dictate the emergence of self-replicative function and defines the structural space within which this behaviour is observed.

Original languageEnglish
Pages (from-to)8798-8812
Number of pages15
JournalChemistry - A European Journal
Volume12
Issue number34
DOIs
Publication statusPublished - 24 Nov 2006

Keywords

  • kinetics
  • molecular recognition
  • recognition-mediated reactions
  • self-replication
  • supramolecular chemistry
  • DIELS-ALDER REACTION
  • RECOGNITION-INDUCED CONTROL
  • DIPOLAR CYCLOADDITION REACTION
  • INTRAMOLECULAR REACTIONS
  • ENANTIOMERIC EXCESS
  • METABOLIC NETWORKS
  • ASYMMETRIC AUTOCATALYSIS
  • SUPRAMOLECULAR CHEMISTRY
  • MOLECULAR RECOGNITION
  • EFFECTIVE MOLARITIES

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