Probing phosphoinositide functions in signaling and membrane trafficking

C Peter Downes; Alex Gray; John M Lucocq

doi:10.1016/j.tcb.2005.03.008

Probing phosphoinositide functions in signaling and membrane trafficking

C Peter Downes, Alex Gray, John M Lucocq

Research output: Contribution to journal › Article › peer-review

198 Citations (Scopus)

Abstract

The inositol phospholipids (PIs) comprise a family of eight species with different combinations of phosphate groups arranged around the inositol ring. PIs are among the most versatile signaling molecules known, with key roles in receptor-mediated signal transduction, actin remodeling and membrane trafficking. Recent studies have identified effector proteins and specific lipid-binding domains through which PIs signal. These lipid-binding domains can be used as probes to further our understanding of the spatial and temporal control of individual PI species. New layers of complexity revealed by the use of such probes include the occurrence of PIs at intracellular locations, the identification of phosphatidylinositol signaling hotspots and the presence of non-membrane pools of PIs in cell nuclei.

Original language	English
Pages (from-to)	259-68
Number of pages	10
Journal	Trends in Cell Biology
Volume	15
Issue number	5
DOIs	https://doi.org/10.1016/j.tcb.2005.03.008
Publication status	Published - May 2005

Keywords

Cell Membrane
Intracellular Membranes
Membrane Lipids
Models, Biological
Phosphatidylinositol 3-Kinases
Phosphatidylinositol 4,5-Diphosphate
Phosphatidylinositols
Protein Binding
Signal Transduction

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10.1016/j.tcb.2005.03.008

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title = "Probing phosphoinositide functions in signaling and membrane trafficking",

abstract = "The inositol phospholipids (PIs) comprise a family of eight species with different combinations of phosphate groups arranged around the inositol ring. PIs are among the most versatile signaling molecules known, with key roles in receptor-mediated signal transduction, actin remodeling and membrane trafficking. Recent studies have identified effector proteins and specific lipid-binding domains through which PIs signal. These lipid-binding domains can be used as probes to further our understanding of the spatial and temporal control of individual PI species. New layers of complexity revealed by the use of such probes include the occurrence of PIs at intracellular locations, the identification of phosphatidylinositol signaling hotspots and the presence of non-membrane pools of PIs in cell nuclei.",

keywords = "Cell Membrane, Intracellular Membranes, Membrane Lipids, Models, Biological, Phosphatidylinositol 3-Kinases, Phosphatidylinositol 4,5-Diphosphate, Phosphatidylinositols, Protein Binding, Signal Transduction",

author = "Downes, {C Peter} and Alex Gray and Lucocq, {John M}",

year = "2005",

month = may,

doi = "10.1016/j.tcb.2005.03.008",

language = "English",

volume = "15",

pages = "259--68",

journal = "Trends in Cell Biology",

issn = "0962-8924",

publisher = "Elsevier",

number = "5",

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TY - JOUR

T1 - Probing phosphoinositide functions in signaling and membrane trafficking

AU - Downes, C Peter

AU - Gray, Alex

AU - Lucocq, John M

PY - 2005/5

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N2 - The inositol phospholipids (PIs) comprise a family of eight species with different combinations of phosphate groups arranged around the inositol ring. PIs are among the most versatile signaling molecules known, with key roles in receptor-mediated signal transduction, actin remodeling and membrane trafficking. Recent studies have identified effector proteins and specific lipid-binding domains through which PIs signal. These lipid-binding domains can be used as probes to further our understanding of the spatial and temporal control of individual PI species. New layers of complexity revealed by the use of such probes include the occurrence of PIs at intracellular locations, the identification of phosphatidylinositol signaling hotspots and the presence of non-membrane pools of PIs in cell nuclei.

AB - The inositol phospholipids (PIs) comprise a family of eight species with different combinations of phosphate groups arranged around the inositol ring. PIs are among the most versatile signaling molecules known, with key roles in receptor-mediated signal transduction, actin remodeling and membrane trafficking. Recent studies have identified effector proteins and specific lipid-binding domains through which PIs signal. These lipid-binding domains can be used as probes to further our understanding of the spatial and temporal control of individual PI species. New layers of complexity revealed by the use of such probes include the occurrence of PIs at intracellular locations, the identification of phosphatidylinositol signaling hotspots and the presence of non-membrane pools of PIs in cell nuclei.

KW - Cell Membrane

KW - Intracellular Membranes

KW - Membrane Lipids

KW - Models, Biological

KW - Phosphatidylinositol 3-Kinases

KW - Phosphatidylinositol 4,5-Diphosphate

KW - Phosphatidylinositols

KW - Protein Binding

KW - Signal Transduction

U2 - 10.1016/j.tcb.2005.03.008

DO - 10.1016/j.tcb.2005.03.008

M3 - Article

C2 - 15866030

SN - 0962-8924

VL - 15

SP - 259

EP - 268

JO - Trends in Cell Biology

JF - Trends in Cell Biology

IS - 5

ER -

Probing phosphoinositide functions in signaling and membrane trafficking

Abstract

Keywords

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