Prevalence of chronic pain in LTCs and multimorbidity: a cross-sectional study using UK Biobank

Ross McQueenie, Bhautesh Dinesh Jani, Stefan Siebert, Philip McLoone, Colin McCowan, Sara Macdonald, Frances S Mair, Barbara I Nicholl*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives:
Chronic pain is often experienced alongside other long-term conditions (LTCs), yet our understanding of this, particularly in relation to multimorbidity (≥2 LTCs) is poor. We aimed to examine associations between the presence/extent of chronic pain with type/number of LTCs experienced.

Methods:
We examined the relationship between number/type of LTCs (N = 45) in UK Biobank participants (n = 500,295) who self-reported chronic pain lasting ≥3 months in seven body sites or widespread. Relative risk ratios (RRR) for presence/extent of chronic pain sites were compared using logistic regression adjusted for sociodemographic (sex/age/socioeconomic status) and lifestyle factors (smoking/alcohol intake/BMI/physical activity).

Results:
218,648 participants self-reported chronic pain. Of these, 69.1% reported ≥1 LTC and 36.2% reported ≥2 LTCs. In 31/45 LTCs examined, >50% of participants experienced chronic pain. Chronic pain was common with migraine/headache and irritable bowel syndrome where pain is a primary symptom, but also with mental health conditions and diseases of the digestive system. Participants with >4 LTCs were over three times as likely to have chronic pain (RRR 3.56, 95% confidence intervals (CIs) 3.44–3.68) and 20 times as likely to have widespread chronic pain (RRR 20.13, 95% CI 18.26–22.19) as those with no LTCs.

Conclusions:
Chronic pain is extremely common across a wide range of LTCs. People with multimorbidity were at higher risk of having a greater extent of chronic pain. These results show that chronic pain is a key factor for consideration in the management of patients with LTCs or multimorbidity.
Original languageEnglish
Number of pages10
JournalJournal of Multimorbidity and Comorbidity
Volume11
Early online date21 Dec 2021
DOIs
Publication statusE-pub ahead of print - 21 Dec 2021

Keywords

  • Chronic pain
  • Prevalence
  • Multimorbidity
  • Long-term conditions

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