TY - JOUR
T1 - Preparation of acyclo nucleoside phosphonate analogues based on cross-metathesis
AU - Kumamoto, Hiroki
AU - Topalis, Dimitri
AU - Broggi, Julie
AU - Pradere, Ugo
AU - Roy, Vincent
AU - Berteina-Raboin, Sabine
AU - Nolan, Steven Patrick
AU - Deville-Bonne, Dominique
AU - Andrei, Graciela
AU - Snoeck, Robert
AU - Garin, Daniel
AU - Crance, Jean-Marc
AU - Agrofoglio, Luigi A.
PY - 2008/4/14
Y1 - 2008/4/14
N2 - In our on-going program targeting anti-pox activity, we report here the synthesis of hitherto unknown acyclic nucleoside phosphonates using olefin cross-metathesis (CM) as a key assembly step. Modification at the C-5 position of the uracil moiety was performed under optimized Pd(0)-catalyzed Stille cross-coupling conditions. None of the obtained compounds were active against poxviruses, nor do they exhibit any toxicity. (c) 2008 Elsevier Ltd. All rights reserved.
AB - In our on-going program targeting anti-pox activity, we report here the synthesis of hitherto unknown acyclic nucleoside phosphonates using olefin cross-metathesis (CM) as a key assembly step. Modification at the C-5 position of the uracil moiety was performed under optimized Pd(0)-catalyzed Stille cross-coupling conditions. None of the obtained compounds were active against poxviruses, nor do they exhibit any toxicity. (c) 2008 Elsevier Ltd. All rights reserved.
KW - RING-CLOSING METATHESIS
KW - ANTIVIRAL ACTIVITY
KW - OLEFIN METATHESIS
KW - CATALYZED HYDROPHOSPHORYLATION
KW - CIDOFOVIR
KW - DERIVATIVES
KW - LIGANDS
KW - REARRANGEMENT
KW - HETEROCYCLES
KW - NUCLEOTIDES
UR - http://www.scopus.com/inward/record.url?scp=39849086493&partnerID=8YFLogxK
U2 - 10.1016/j.tet.2008.01.140
DO - 10.1016/j.tet.2008.01.140
M3 - Article
SN - 0040-4020
VL - 64
SP - 3517
EP - 3526
JO - Tetrahedron
JF - Tetrahedron
IS - 16
ER -