Predicted role of Mitsugumin 23 in skeletal and cardiac muscle

Daiki Watanabe; Richard C. Edel; Miyuki Nishi; Hiroshi Takeshima; Samantha J. Pitt

doi:10.3390/cells14241958

Predicted role of Mitsugumin 23 in skeletal and cardiac muscle

Daiki Watanabe
, Richard C. Edel
, Miyuki Nishi
, Hiroshi Takeshima
, Samantha J. Pitt

Research output: Contribution to journal › Review article › peer-review

Abstract

Mitsugumin 23 (MG23) is a transmembrane protein expressed in the nuclear membrane and endo/sarcoplasmic reticulum (ER/SR) of various tissues, including skeletal and cardiac muscle. MG23 is a non-selective cation channel that has been implicated in the leakage of calcium ions (Ca2+) under diverse pathophysiological conditions. SR Ca2+ leak is considered to be a contributing factor of skeletal muscle weakness and is also implicated in the progression of heart failure. The absence of MG23 has been reported to alleviate negative outcomes associated with SR Ca2+ leak. Targeting MG23 could represent a new therapeutic strategy against muscle disorders. This review discusses the potential role of MG23 in skeletal and cardiac muscle, and highlights MG23 as both a regulator of basal SR Ca2+-handling and a mediator of pathophysiological remodelling in muscle.

Original language	English
Article number	1958
Journal	Cells
Volume	14
Issue number	24
DOIs	https://doi.org/10.3390/cells14241958
Publication status	Published - 10 Dec 2025

Keywords

Mitsugumin23/TMEM109
Sarcoplasmic reticulum
Calcium regulation

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Copyright © 2025 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
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@article{38b39a81872541a6b8e2b0152a5cfaaa,

title = "Predicted role of Mitsugumin 23 in skeletal and cardiac muscle",

abstract = "Mitsugumin 23 (MG23) is a transmembrane protein expressed in the nuclear membrane and endo/sarcoplasmic reticulum (ER/SR) of various tissues, including skeletal and cardiac muscle. MG23 is a non-selective cation channel that has been implicated in the leakage of calcium ions (Ca2+) under diverse pathophysiological conditions. SR Ca2+ leak is considered to be a contributing factor of skeletal muscle weakness and is also implicated in the progression of heart failure. The absence of MG23 has been reported to alleviate negative outcomes associated with SR Ca2+ leak. Targeting MG23 could represent a new therapeutic strategy against muscle disorders. This review discusses the potential role of MG23 in skeletal and cardiac muscle, and highlights MG23 as both a regulator of basal SR Ca2+-handling and a mediator of pathophysiological remodelling in muscle.",

keywords = "Mitsugumin23/TMEM109, Sarcoplasmic reticulum, Calcium regulation",

author = "Daiki Watanabe and Edel, \{Richard C.\} and Miyuki Nishi and Hiroshi Takeshima and Pitt, \{Samantha J.\}",

note = "Funding: This work was supported by Japan Society for the Promotion of Science (to D. Watanabe, No. 23K24738 and No. 23KK0297; to M. Nishi, 20K10634; to H. Takeshima, 21H02663). R.C.E is supported by a BBSRC funded EastBio studentship BB/T00875X/1.",

year = "2025",

month = dec,

day = "10",

doi = "10.3390/cells14241958",

language = "English",

volume = "14",

journal = "Cells",

issn = "2073-4409",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "24",

}

TY - JOUR

T1 - Predicted role of Mitsugumin 23 in skeletal and cardiac muscle

AU - Watanabe, Daiki

AU - Edel, Richard C.

AU - Nishi, Miyuki

AU - Takeshima, Hiroshi

AU - Pitt, Samantha J.

N1 - Funding: This work was supported by Japan Society for the Promotion of Science (to D. Watanabe, No. 23K24738 and No. 23KK0297; to M. Nishi, 20K10634; to H. Takeshima, 21H02663). R.C.E is supported by a BBSRC funded EastBio studentship BB/T00875X/1.

PY - 2025/12/10

Y1 - 2025/12/10

N2 - Mitsugumin 23 (MG23) is a transmembrane protein expressed in the nuclear membrane and endo/sarcoplasmic reticulum (ER/SR) of various tissues, including skeletal and cardiac muscle. MG23 is a non-selective cation channel that has been implicated in the leakage of calcium ions (Ca2+) under diverse pathophysiological conditions. SR Ca2+ leak is considered to be a contributing factor of skeletal muscle weakness and is also implicated in the progression of heart failure. The absence of MG23 has been reported to alleviate negative outcomes associated with SR Ca2+ leak. Targeting MG23 could represent a new therapeutic strategy against muscle disorders. This review discusses the potential role of MG23 in skeletal and cardiac muscle, and highlights MG23 as both a regulator of basal SR Ca2+-handling and a mediator of pathophysiological remodelling in muscle.

AB - Mitsugumin 23 (MG23) is a transmembrane protein expressed in the nuclear membrane and endo/sarcoplasmic reticulum (ER/SR) of various tissues, including skeletal and cardiac muscle. MG23 is a non-selective cation channel that has been implicated in the leakage of calcium ions (Ca2+) under diverse pathophysiological conditions. SR Ca2+ leak is considered to be a contributing factor of skeletal muscle weakness and is also implicated in the progression of heart failure. The absence of MG23 has been reported to alleviate negative outcomes associated with SR Ca2+ leak. Targeting MG23 could represent a new therapeutic strategy against muscle disorders. This review discusses the potential role of MG23 in skeletal and cardiac muscle, and highlights MG23 as both a regulator of basal SR Ca2+-handling and a mediator of pathophysiological remodelling in muscle.

KW - Mitsugumin23/TMEM109

KW - Sarcoplasmic reticulum

KW - Calcium regulation

U2 - 10.3390/cells14241958

DO - 10.3390/cells14241958

M3 - Review article

SN - 2073-4409

VL - 14

JO - Cells

JF - Cells

IS - 24

M1 - 1958

ER -

Predicted role of Mitsugumin 23 in skeletal and cardiac muscle

Abstract

Keywords

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