Pre-clinical bioimaging in a mouse model of rheumatoid arthritis

Michelle Ierna; Karen Smith; Kirsty Ross; Gordon Meiklejohn; Pasquale Maffia; James M. Brewer; Iain B. McInnes; Paul Garside

Pre-clinical bioimaging in a mouse model of rheumatoid arthritis

Michelle Ierna, Karen Smith, Kirsty Ross, Gordon Meiklejohn, Pasquale Maffia, James M. Brewer, Iain B. McInnes, Paul Garside^*

^*Corresponding author for this work

School of Computer Science

Research output: Contribution to conference › Abstract › peer-review

Abstract

The early detection of changes to molecular pathways underlying Rheumatoid Arthritis (RA) is a key goal in Rheumatology. However, the standard disease scoring methods employed in the standard mouse model of RA, Collagen Induced Arthritis (CIA) cannot adequately quantify cellular or molecular processes. Here, we show that biofluorescence imaging can track in vivo processes contributing to disease and allow comparisons to be made of therapeutic drug efficacy earlier in disease progression.

Original language	English
Pages	S75-S75
Publication status	Published - 6 Oct 2011

Keywords

bioimaging
rheumatoid arthritis
arthritis
rheumatism

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https://acrabstracts.org/wp-content/uploads/2018/06/2011_ACR_ARHP_Abstract_Supplement.pdfLicence: CC BY

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title = "Pre-clinical bioimaging in a mouse model of rheumatoid arthritis",

abstract = "The early detection of changes to molecular pathways underlying Rheumatoid Arthritis (RA) is a key goal in Rheumatology. However, the standard disease scoring methods employed in the standard mouse model of RA, Collagen Induced Arthritis (CIA) cannot adequately quantify cellular or molecular processes. Here, we show that biofluorescence imaging can track in vivo processes contributing to disease and allow comparisons to be made of therapeutic drug efficacy earlier in disease progression.",

keywords = "bioimaging, rheumatoid arthritis, arthritis, rheumatism",

author = "Michelle Ierna and Karen Smith and Kirsty Ross and Gordon Meiklejohn and Pasquale Maffia and Brewer, {James M.} and McInnes, {Iain B.} and Paul Garside",

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AU - Ierna, Michelle

AU - Smith, Karen

AU - Ross, Kirsty

AU - Meiklejohn, Gordon

AU - Maffia, Pasquale

AU - Brewer, James M.

AU - McInnes, Iain B.

AU - Garside, Paul

PY - 2011/10/6

Y1 - 2011/10/6

N2 - The early detection of changes to molecular pathways underlying Rheumatoid Arthritis (RA) is a key goal in Rheumatology. However, the standard disease scoring methods employed in the standard mouse model of RA, Collagen Induced Arthritis (CIA) cannot adequately quantify cellular or molecular processes. Here, we show that biofluorescence imaging can track in vivo processes contributing to disease and allow comparisons to be made of therapeutic drug efficacy earlier in disease progression.

AB - The early detection of changes to molecular pathways underlying Rheumatoid Arthritis (RA) is a key goal in Rheumatology. However, the standard disease scoring methods employed in the standard mouse model of RA, Collagen Induced Arthritis (CIA) cannot adequately quantify cellular or molecular processes. Here, we show that biofluorescence imaging can track in vivo processes contributing to disease and allow comparisons to be made of therapeutic drug efficacy earlier in disease progression.

KW - bioimaging

KW - rheumatoid arthritis

KW - arthritis

KW - rheumatism

M3 - Abstract

SP - S75-S75

ER -

Pre-clinical bioimaging in a mouse model of rheumatoid arthritis

Abstract

Keywords

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