Potential drug targets in the pentose phosphate pathway of trypanosomatids

Ines Loureiro, Joana Faria, Nuno Santarem, Terry K. Smith, Joana Tavares, Anabela Cordeiro-da-Silva

Research output: Contribution to journalReview articlepeer-review

15 Citations (Scopus)

Abstract

The trypanosomatids, Trypanosoma brucei, Trypanosoma cruzi and Leishmania spp, are causative agents of important human diseases such as African sleeping sickness, Chagas' disease and Leishmaniasis, respectively. The high impact of these diseases on human health and economy worldwide, the unsatisfactory available chemotherapeutic options and the absence of human effective vaccines, strongly justifies the search for new drugs. The pentose phosphate pathway has been proposed to be a viable strategy to defeat several infectious diseases, including those from trypanosomatids, as it includes an oxidative branch, important in the maintenance of cell redox homeostasis, and a non-oxidative branch in which ribose 5-phosphate and erythrose 4-phosphate, precursors of nucleic acids and aromatic amino acids, are produced. This review provides an overview of the available chemotherapeutic options against these diseases and discusses the potential of genetically validated enzymes from the pentose phosphate pathway of trypanosomatids to be explored as potential drug targets.
Original languageEnglish
Pages (from-to)5239-5265
Number of pages27
JournalCurrent Medicinal Chemistry
Volume25
Issue number39
DOIs
Publication statusPublished - 30 Nov 2018

Keywords

  • Trypanosomatids
  • Treatment
  • Pentose phosphate pathway
  • Drug targets

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