Porous, rigid metal(III)-carboxylate metal-organic frameworks for the delivery of nitric oxide

J.F. Eubank; P.S. Wheatley; G. Lebars; A.C. McKinlay; H. Leclerc; P. Horcajada; M. Daturi; A. Vimont; R.E. Morris; C. Serre

doi:10.1063/1.4904069

Porous, rigid metal(III)-carboxylate metal-organic frameworks for the delivery of nitric oxide

J.F. Eubank, P.S. Wheatley, G. Lebars, A.C. McKinlay, H. Leclerc, P. Horcajada, M. Daturi, A. Vimont, R.E. Morris, C. Serre

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Abstract

The room temperature sorption properties of the biological gas nitric oxide (NO) have been investigated on the highly porous and rigid iron or chromium carboxylate based metal-organic frameworks Material Institut Lavoisier (MIL)-100(Fe or Cr) and MIL-127(Fe). In all cases, a significant amount of NO is chemisorbed at 298 K with a loading capacity that depends both on the nature of the metal cation, the structure and the presence of additional iron(II) Lewis acid sites. In a second step, the release of NO triggered by wet nitrogen gas has been studied by chemiluminescence and indicates that only a partial release of NO occurs as well as a prolonged delivery at the biological level. Finally, an in situ infrared spectroscopy study confirms not only the coordination of NO over the Lewis acid sites and the stronger binding of NO on the additional iron(II) sites, providing further insights over the partial release of NO only in the presence of water at room temperature.

Original language	English
Article number	124112
Journal	APL Materials
Volume	2
Issue number	12
DOIs	https://doi.org/10.1063/1.4904069
Publication status	Published - Dec 2014

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@article{93b882f17bad4a2bb6c8c5fb38676a0e,

title = "Porous, rigid metal(III)-carboxylate metal-organic frameworks for the delivery of nitric oxide",

abstract = "The room temperature sorption properties of the biological gas nitric oxide (NO) have been investigated on the highly porous and rigid iron or chromium carboxylate based metal-organic frameworks Material Institut Lavoisier (MIL)-100(Fe or Cr) and MIL-127(Fe). In all cases, a significant amount of NO is chemisorbed at 298 K with a loading capacity that depends both on the nature of the metal cation, the structure and the presence of additional iron(II) Lewis acid sites. In a second step, the release of NO triggered by wet nitrogen gas has been studied by chemiluminescence and indicates that only a partial release of NO occurs as well as a prolonged delivery at the biological level. Finally, an in situ infrared spectroscopy study confirms not only the coordination of NO over the Lewis acid sites and the stronger binding of NO on the additional iron(II) sites, providing further insights over the partial release of NO only in the presence of water at room temperature.",

author = "J.F. Eubank and P.S. Wheatley and G. Lebars and A.C. McKinlay and H. Leclerc and P. Horcajada and M. Daturi and A. Vimont and R.E. Morris and C. Serre",

note = "This work was supported by CNRS, EU through the ERC-2007-209241-BioMOFs ERC grant (J.F.E., P.H., C.S.). R.E.M. thanks the GEMI Fund and the E.P.S.R.C for funding. R.E.M is a Royal Society Wolfson Merit Award Holder. ",

year = "2014",

month = dec,

doi = "10.1063/1.4904069",

language = "English",

volume = "2",

journal = "APL Materials",

issn = "2166-532X",

publisher = "American Institute of Physics",

number = "12",

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TY - JOUR

T1 - Porous, rigid metal(III)-carboxylate metal-organic frameworks for the delivery of nitric oxide

AU - Eubank, J.F.

AU - Wheatley, P.S.

AU - Lebars, G.

AU - McKinlay, A.C.

AU - Leclerc, H.

AU - Horcajada, P.

AU - Daturi, M.

AU - Vimont, A.

AU - Morris, R.E.

AU - Serre, C.

N1 - This work was supported by CNRS, EU through the ERC-2007-209241-BioMOFs ERC grant (J.F.E., P.H., C.S.). R.E.M. thanks the GEMI Fund and the E.P.S.R.C for funding. R.E.M is a Royal Society Wolfson Merit Award Holder.

PY - 2014/12

Y1 - 2014/12

N2 - The room temperature sorption properties of the biological gas nitric oxide (NO) have been investigated on the highly porous and rigid iron or chromium carboxylate based metal-organic frameworks Material Institut Lavoisier (MIL)-100(Fe or Cr) and MIL-127(Fe). In all cases, a significant amount of NO is chemisorbed at 298 K with a loading capacity that depends both on the nature of the metal cation, the structure and the presence of additional iron(II) Lewis acid sites. In a second step, the release of NO triggered by wet nitrogen gas has been studied by chemiluminescence and indicates that only a partial release of NO occurs as well as a prolonged delivery at the biological level. Finally, an in situ infrared spectroscopy study confirms not only the coordination of NO over the Lewis acid sites and the stronger binding of NO on the additional iron(II) sites, providing further insights over the partial release of NO only in the presence of water at room temperature.

AB - The room temperature sorption properties of the biological gas nitric oxide (NO) have been investigated on the highly porous and rigid iron or chromium carboxylate based metal-organic frameworks Material Institut Lavoisier (MIL)-100(Fe or Cr) and MIL-127(Fe). In all cases, a significant amount of NO is chemisorbed at 298 K with a loading capacity that depends both on the nature of the metal cation, the structure and the presence of additional iron(II) Lewis acid sites. In a second step, the release of NO triggered by wet nitrogen gas has been studied by chemiluminescence and indicates that only a partial release of NO occurs as well as a prolonged delivery at the biological level. Finally, an in situ infrared spectroscopy study confirms not only the coordination of NO over the Lewis acid sites and the stronger binding of NO on the additional iron(II) sites, providing further insights over the partial release of NO only in the presence of water at room temperature.

U2 - 10.1063/1.4904069

DO - 10.1063/1.4904069

M3 - Article

AN - SCOPUS:84920261081

SN - 2166-532X

VL - 2

JO - APL Materials

JF - APL Materials

IS - 12

M1 - 124112

ER -

Porous, rigid metal(III)-carboxylate metal-organic frameworks for the delivery of nitric oxide

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