Poor Memory Performance in Aged Cynomolgus Monkeys with Hippocampal Atrophy, Depletion of Amyloid Beta 1-42 and Accumulation of Tau Proteins in Cerebrospinal Fluid

Huda S. Darusman; Jacub Pandelaki; Rahmad Mulyadi; Dondin Sajuthi; Indah A. Putri; Otto H. Kalliokoski; Josep Call; Klas S. P. Abelson; Steven J. Schapiro; Albert Gjedde; Jann Hau

Poor Memory Performance in Aged Cynomolgus Monkeys with Hippocampal Atrophy, Depletion of Amyloid Beta 1-42 and Accumulation of Tau Proteins in Cerebrospinal Fluid

Huda S. Darusman^*, Jacub Pandelaki, Rahmad Mulyadi, Dondin Sajuthi, Indah A. Putri, Otto H. Kalliokoski, Josep Call, Klas S. P. Abelson, Steven J. Schapiro, Albert Gjedde, Jann Hau

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Due to their similarities in behavior and disease pathology to humans, non-human primate models are desirable to complement small animals as models for the study of age-related dementia. Materials and Methods: Based on their performance on delayed response task (DRT) tests of memory, aged cynomolgus monkeys were divided into two groups to compare high-performing (n=6) and low-performing (n=6) subjects. Both groups were tested for biomarkers related to Alzheimer's disease and their brains were scanned using structural magnetic resonance imaging. Results: The subjects with poor DRT performance had evidence of atrophy in the hippocampus and cortical areas, significantly lower cerebrospinal fluid levels of amyloid beta amino acid 1-42 (p

Original language	English
Pages (from-to)	173-184
Number of pages	12
Journal	In vivo
Volume	28
Issue number	2
Publication status	Published - 2014

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Neurodegenerative disease
non-human primate
memory
biomarkers
magnetic resonance imaging
MILD COGNITIVE IMPAIRMENT
PAIRED HELICAL FILAMENTS
CHIMPANZEES PAN-TROGLODYTES
SHORT-TERM-MEMORY
ALZHEIMERS-DISEASE
RHESUS-MONKEYS
MACACA-FASCICULARIS
DELAYED-RESPONSE
RECOGNITION MEMORY
ANIMAL-MODELS

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title = "Poor Memory Performance in Aged Cynomolgus Monkeys with Hippocampal Atrophy, Depletion of Amyloid Beta 1-42 and Accumulation of Tau Proteins in Cerebrospinal Fluid",

abstract = "Background: Due to their similarities in behavior and disease pathology to humans, non-human primate models are desirable to complement small animals as models for the study of age-related dementia. Materials and Methods: Based on their performance on delayed response task (DRT) tests of memory, aged cynomolgus monkeys were divided into two groups to compare high-performing (n=6) and low-performing (n=6) subjects. Both groups were tested for biomarkers related to Alzheimer's disease and their brains were scanned using structural magnetic resonance imaging. Results: The subjects with poor DRT performance had evidence of atrophy in the hippocampus and cortical areas, significantly lower cerebrospinal fluid levels of amyloid beta amino acid 1-42 (p",

keywords = "Neurodegenerative disease, non-human primate, memory, biomarkers, magnetic resonance imaging, MILD COGNITIVE IMPAIRMENT, PAIRED HELICAL FILAMENTS, CHIMPANZEES PAN-TROGLODYTES, SHORT-TERM-MEMORY, ALZHEIMERS-DISEASE, RHESUS-MONKEYS, MACACA-FASCICULARIS, DELAYED-RESPONSE, RECOGNITION MEMORY, ANIMAL-MODELS",

author = "Darusman, \{Huda S.\} and Jacub Pandelaki and Rahmad Mulyadi and Dondin Sajuthi and Putri, \{Indah A.\} and Kalliokoski, \{Otto H.\} and Josep Call and Abelson, \{Klas S. P.\} and Schapiro, \{Steven J.\} and Albert Gjedde and Jann Hau",

year = "2014",

language = "English",

volume = "28",

pages = "173--184",

journal = "In vivo",

issn = "0258-851X",

publisher = "International Institute of Anticancer Research",

number = "2",

}

TY - JOUR

T1 - Poor Memory Performance in Aged Cynomolgus Monkeys with Hippocampal Atrophy, Depletion of Amyloid Beta 1-42 and Accumulation of Tau Proteins in Cerebrospinal Fluid

AU - Darusman, Huda S.

AU - Pandelaki, Jacub

AU - Mulyadi, Rahmad

AU - Sajuthi, Dondin

AU - Putri, Indah A.

AU - Kalliokoski, Otto H.

AU - Call, Josep

AU - Abelson, Klas S. P.

AU - Schapiro, Steven J.

AU - Gjedde, Albert

AU - Hau, Jann

PY - 2014

Y1 - 2014

N2 - Background: Due to their similarities in behavior and disease pathology to humans, non-human primate models are desirable to complement small animals as models for the study of age-related dementia. Materials and Methods: Based on their performance on delayed response task (DRT) tests of memory, aged cynomolgus monkeys were divided into two groups to compare high-performing (n=6) and low-performing (n=6) subjects. Both groups were tested for biomarkers related to Alzheimer's disease and their brains were scanned using structural magnetic resonance imaging. Results: The subjects with poor DRT performance had evidence of atrophy in the hippocampus and cortical areas, significantly lower cerebrospinal fluid levels of amyloid beta amino acid 1-42 (p

AB - Background: Due to their similarities in behavior and disease pathology to humans, non-human primate models are desirable to complement small animals as models for the study of age-related dementia. Materials and Methods: Based on their performance on delayed response task (DRT) tests of memory, aged cynomolgus monkeys were divided into two groups to compare high-performing (n=6) and low-performing (n=6) subjects. Both groups were tested for biomarkers related to Alzheimer's disease and their brains were scanned using structural magnetic resonance imaging. Results: The subjects with poor DRT performance had evidence of atrophy in the hippocampus and cortical areas, significantly lower cerebrospinal fluid levels of amyloid beta amino acid 1-42 (p

KW - Neurodegenerative disease

KW - non-human primate

KW - memory

KW - biomarkers

KW - magnetic resonance imaging

KW - MILD COGNITIVE IMPAIRMENT

KW - PAIRED HELICAL FILAMENTS

KW - CHIMPANZEES PAN-TROGLODYTES

KW - SHORT-TERM-MEMORY

KW - ALZHEIMERS-DISEASE

KW - RHESUS-MONKEYS

KW - MACACA-FASCICULARIS

KW - DELAYED-RESPONSE

KW - RECOGNITION MEMORY

KW - ANIMAL-MODELS

UR - http://iv.iiarjournals.org/content/28/2/173.long

UR - https://www.scopus.com/pages/publications/84908554770

M3 - Article

SN - 0258-851X

VL - 28

SP - 173

EP - 184

JO - In vivo

JF - In vivo

IS - 2

ER -

Poor Memory Performance in Aged Cynomolgus Monkeys with Hippocampal Atrophy, Depletion of Amyloid Beta 1-42 and Accumulation of Tau Proteins in Cerebrospinal Fluid

Abstract

UN SDGs

Keywords

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