Poor Memory Performance in Aged Cynomolgus Monkeys with Hippocampal Atrophy, Depletion of Amyloid Beta 1-42 and Accumulation of Tau Proteins in Cerebrospinal Fluid

Huda S. Darusman*, Jacub Pandelaki, Rahmad Mulyadi, Dondin Sajuthi, Indah A. Putri, Otto H. Kalliokoski, Josep Call, Klas S. P. Abelson, Steven J. Schapiro, Albert Gjedde, Jann Hau

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)

Abstract

Background: Due to their similarities in behavior and disease pathology to humans, non-human primate models are desirable to complement small animals as models for the study of age-related dementia. Materials and Methods: Based on their performance on delayed response task (DRT) tests of memory, aged cynomolgus monkeys were divided into two groups to compare high-performing (n=6) and low-performing (n=6) subjects. Both groups were tested for biomarkers related to Alzheimer's disease and their brains were scanned using structural magnetic resonance imaging. Results: The subjects with poor DRT performance had evidence of atrophy in the hippocampus and cortical areas, significantly lower cerebrospinal fluid levels of amyloid beta amino acid 1-42 (p

Original languageEnglish
Pages (from-to)173-184
Number of pages12
JournalIn vivo
Volume28
Issue number2
Publication statusPublished - 2014

Keywords

  • Neurodegenerative disease
  • non-human primate
  • memory
  • biomarkers
  • magnetic resonance imaging
  • MILD COGNITIVE IMPAIRMENT
  • PAIRED HELICAL FILAMENTS
  • CHIMPANZEES PAN-TROGLODYTES
  • SHORT-TERM-MEMORY
  • ALZHEIMERS-DISEASE
  • RHESUS-MONKEYS
  • MACACA-FASCICULARIS
  • DELAYED-RESPONSE
  • RECOGNITION MEMORY
  • ANIMAL-MODELS

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