TY - JOUR
T1 - Pneumococcal polysaccharide vaccine: A systematic review of clinical effectiveness in adults
AU - Watson, L.
AU - Wilson, B.J.
AU - Waugh, N.
N1 - Cited By :110
Export Date: 12 March 2018
CODEN: VACCD
PY - 2002
Y1 - 2002
N2 - Pneumococcal polysaccharide vaccine is recommended in western countries for individuals at high risk of pneumococcal illness. We undertook a systematic review of randomised controlled trials of pneumococcal vaccine in adults, to determine the effects on clinical outcomes. Results: In industrialised populations, no benefit was detected for outcomes other than pneumococcal bacteraemia, and this did not reach statistical significance. In non-industrial populations, clear benefit was demonstrated for mortality and all-cause pneumonia. Conclusion: Benefit from pneumococcal vaccination depends on the baseline risk of infection and characteristics of a given population. Evidence from randomised trials for widespread adult vaccination in industrial countries is lacking. © 2002 Elsevier Science Ltd. All rights reserved.
AB - Pneumococcal polysaccharide vaccine is recommended in western countries for individuals at high risk of pneumococcal illness. We undertook a systematic review of randomised controlled trials of pneumococcal vaccine in adults, to determine the effects on clinical outcomes. Results: In industrialised populations, no benefit was detected for outcomes other than pneumococcal bacteraemia, and this did not reach statistical significance. In non-industrial populations, clear benefit was demonstrated for mortality and all-cause pneumonia. Conclusion: Benefit from pneumococcal vaccination depends on the baseline risk of infection and characteristics of a given population. Evidence from randomised trials for widespread adult vaccination in industrial countries is lacking. © 2002 Elsevier Science Ltd. All rights reserved.
U2 - 10.1016/S0264-410X(02)00112-3
DO - 10.1016/S0264-410X(02)00112-3
M3 - Article
SN - 0264-410X
VL - 20
SP - 2166
EP - 2173
JO - Vaccine
JF - Vaccine
IS - 17-18
ER -