PI3K signalling during influenza A virus infections

B. G. Hale, R. E. Randall

Research output: Contribution to journalArticlepeer-review

30 Citations (Scopus)

Abstract

Recent work has demonstrated that the PI3K (phosphoinositide 3-kinase) signalling pathway is important for efficient influenza A virus replication. Activation of PI3K in virus-infected cells is mediated by the viral NS1 protein, which binds directly to the p85 beta regulatory subunit of PI3K and causes the PI3K-dependent phosphorylation of Akt (protein kinase B). Given that recombinant influenza A viruses unable to activate PI3K signalling are attenuated in tissue culture, the PI3K pathway could be a novel target for the development of future anti-influenza drugs.

Original languageEnglish
Pages (from-to)186-187
Number of pages2
JournalBiochemical Society Transactions
Volume35
DOIs
Publication statusPublished - Apr 2007

Keywords

  • Akt
  • antiviral drug
  • influenza A virus
  • NS1 protein
  • phosphoinositide 3-kinase (PI3K)
  • p85
  • NS1 PROTEIN

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