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Abstract
Recent work has demonstrated that the PI3K (phosphoinositide 3-kinase) signalling pathway is important for efficient influenza A virus replication. Activation of PI3K in virus-infected cells is mediated by the viral NS1 protein, which binds directly to the p85 beta regulatory subunit of PI3K and causes the PI3K-dependent phosphorylation of Akt (protein kinase B). Given that recombinant influenza A viruses unable to activate PI3K signalling are attenuated in tissue culture, the PI3K pathway could be a novel target for the development of future anti-influenza drugs.
Original language | English |
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Pages (from-to) | 186-187 |
Number of pages | 2 |
Journal | Biochemical Society Transactions |
Volume | 35 |
DOIs | |
Publication status | Published - Apr 2007 |
Keywords
- Akt
- antiviral drug
- influenza A virus
- NS1 protein
- phosphoinositide 3-kinase (PI3K)
- p85
- NS1 PROTEIN
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Dive into the research topics of 'PI3K signalling during influenza A virus infections'. Together they form a unique fingerprint.Projects
- 1 Finished
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Virus NS1 - PI3 G0601126: Studies on the interaction of influenza virus NS1 protein with cellular P13-kinase
Randall, R. E. (PI)
1/10/07 → 31/12/10
Project: Standard