Phyto-oestrogens and risk of prostate cancer in Scottish men

C. L. Heald; M. R. Ritchie; C. Bolton-Smith; M. S. Morton; F. E. Alexander

doi:10.1017/S0007114507700703

Phyto-oestrogens and risk of prostate cancer in Scottish men

C. L. Heald, M. R. Ritchie, C. Bolton-Smith, M. S. Morton, F. E. Alexander

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

A population-based case-control study of diet, inherited susceptibility and prostate cancer was undertaken in the lowlands and central belt of Scotland to investigate the effect of phyto-oestrogen intake and serum concentrations on prostate cancer risk. A total of 433 cases and 483 controls aged 50-74 years were asked to complete a validated FFQ and provide a non-fasting blood sample. Multivariate logistic regression analysis found significant inverse associations with increased serum concentrations of enterolactone (adjusted OR 0.40, 95 % CI 0.22, 0.71] and with the consumption of soy foods (adjusted OR 0.52, 95 % CI 0.30, 0.91). However, no significant associations were observed for isoflavone intake or serum genistein, daidzein and equol. This study supports the hypotheses that soy foods and enterolactone metabolised from dietary lignans protect against prostate cancer in older Scottish men.

Original language	English
Pages (from-to)	388-396
Number of pages	9
Journal	British Journal of Nutrition
Volume	98
DOIs	https://doi.org/10.1017/S0007114507700703
Publication status	Published - Aug 2007

Keywords

prostate cancer
phyto-oestrogens
isoflavones
lignans
soy foods
SERUM ENTEROLACTONE CONCENTRATION
NESTED CASE-CONTROL
FOOD-FREQUENCY QUESTIONNAIRE
UNITED-STATES
PHYTOESTROGEN EXPOSURE
GUT MICROFLORA
JAPANESE MEN
TOBACCO USE
SOY FOODS
DIET

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1017/S0007114507700703

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@article{c291e6eba201474e9e067a024a61ad08,

title = "Phyto-oestrogens and risk of prostate cancer in Scottish men",

abstract = "A population-based case-control study of diet, inherited susceptibility and prostate cancer was undertaken in the lowlands and central belt of Scotland to investigate the effect of phyto-oestrogen intake and serum concentrations on prostate cancer risk. A total of 433 cases and 483 controls aged 50-74 years were asked to complete a validated FFQ and provide a non-fasting blood sample. Multivariate logistic regression analysis found significant inverse associations with increased serum concentrations of enterolactone (adjusted OR 0.40, 95 % CI 0.22, 0.71] and with the consumption of soy foods (adjusted OR 0.52, 95 % CI 0.30, 0.91). However, no significant associations were observed for isoflavone intake or serum genistein, daidzein and equol. This study supports the hypotheses that soy foods and enterolactone metabolised from dietary lignans protect against prostate cancer in older Scottish men.",

keywords = "prostate cancer, phyto-oestrogens, isoflavones, lignans, soy foods, SERUM ENTEROLACTONE CONCENTRATION, NESTED CASE-CONTROL, FOOD-FREQUENCY QUESTIONNAIRE, UNITED-STATES, PHYTOESTROGEN EXPOSURE, GUT MICROFLORA, JAPANESE MEN, TOBACCO USE, SOY FOODS, DIET",

author = "Heald, {C. L.} and Ritchie, {M. R.} and C. Bolton-Smith and Morton, {M. S.} and Alexander, {F. E.}",

year = "2007",

month = aug,

doi = "10.1017/S0007114507700703",

language = "English",

volume = "98",

pages = "388--396",

journal = "British Journal of Nutrition",

issn = "0007-1145",

publisher = "Cambridge University Press",

}

TY - JOUR

T1 - Phyto-oestrogens and risk of prostate cancer in Scottish men

AU - Heald, C. L.

AU - Ritchie, M. R.

AU - Bolton-Smith, C.

AU - Morton, M. S.

AU - Alexander, F. E.

PY - 2007/8

Y1 - 2007/8

N2 - A population-based case-control study of diet, inherited susceptibility and prostate cancer was undertaken in the lowlands and central belt of Scotland to investigate the effect of phyto-oestrogen intake and serum concentrations on prostate cancer risk. A total of 433 cases and 483 controls aged 50-74 years were asked to complete a validated FFQ and provide a non-fasting blood sample. Multivariate logistic regression analysis found significant inverse associations with increased serum concentrations of enterolactone (adjusted OR 0.40, 95 % CI 0.22, 0.71] and with the consumption of soy foods (adjusted OR 0.52, 95 % CI 0.30, 0.91). However, no significant associations were observed for isoflavone intake or serum genistein, daidzein and equol. This study supports the hypotheses that soy foods and enterolactone metabolised from dietary lignans protect against prostate cancer in older Scottish men.

AB - A population-based case-control study of diet, inherited susceptibility and prostate cancer was undertaken in the lowlands and central belt of Scotland to investigate the effect of phyto-oestrogen intake and serum concentrations on prostate cancer risk. A total of 433 cases and 483 controls aged 50-74 years were asked to complete a validated FFQ and provide a non-fasting blood sample. Multivariate logistic regression analysis found significant inverse associations with increased serum concentrations of enterolactone (adjusted OR 0.40, 95 % CI 0.22, 0.71] and with the consumption of soy foods (adjusted OR 0.52, 95 % CI 0.30, 0.91). However, no significant associations were observed for isoflavone intake or serum genistein, daidzein and equol. This study supports the hypotheses that soy foods and enterolactone metabolised from dietary lignans protect against prostate cancer in older Scottish men.

KW - prostate cancer

KW - phyto-oestrogens

KW - isoflavones

KW - lignans

KW - soy foods

KW - SERUM ENTEROLACTONE CONCENTRATION

KW - NESTED CASE-CONTROL

KW - FOOD-FREQUENCY QUESTIONNAIRE

KW - UNITED-STATES

KW - PHYTOESTROGEN EXPOSURE

KW - GUT MICROFLORA

KW - JAPANESE MEN

KW - TOBACCO USE

KW - SOY FOODS

KW - DIET

U2 - 10.1017/S0007114507700703

DO - 10.1017/S0007114507700703

M3 - Article

SN - 0007-1145

VL - 98

SP - 388

EP - 396

JO - British Journal of Nutrition

JF - British Journal of Nutrition

ER -

Phyto-oestrogens and risk of prostate cancer in Scottish men

Abstract

Keywords

UN SDGs

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