Phosphorescent cationic iridium(III) complexes dynamically bound to cyclodextrin vesicles: applications in live cell imaging

Frauke Schibilla; Anna Holthenrich; Boyi Song; Anna Lívia Linard Matos; David Grill; Diego Rota Martir; Volker Gerke; Eli Zysman-Colman; Bart Jan Ravoo

doi:10.1039/C8SC02875C

Phosphorescent cationic iridium(III) complexes dynamically bound to cyclodextrin vesicles: applications in live cell imaging

Frauke Schibilla, Anna Holthenrich, Boyi Song, Anna Lívia Linard Matos, David Grill, Diego Rota Martir, Volker Gerke, Eli Zysman-Colman^*, Bart Jan Ravoo

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

We report cationic Ir(III) complexes functionalized with adamantyl groups designed to bind to β-cyclodextrin vesicles (CDV) with high affinity (K_a = 1·10⁶ M^-1). The emission of the complexes is tuned by changing the nature of the cyclometalating ligands. The host-guest adduct of CDV and Ir(III) complexes shows increased and significantly blue-shifted emission due to the lower mobility of the Ir(III)-complexes residing in the less polar environment of the vesicle surface. Ir(III)-decorated CDV are efficiently taken up by cells and can be used in live cell imaging. The CDV act as carriers to transport the phosphorescent complexes into cells where they selectively stain mitochondria.

Original language	English
Pages (from-to)	7822-7828
Number of pages	7
Journal	Chemical Science
Volume	9
Issue number	40
Early online date	9 Aug 2018
DOIs	https://doi.org/10.1039/C8SC02875C
Publication status	Published - 28 Oct 2018

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10.1039/C8SC02875CLicence: CC BY

Zysman-Colman_2018_CS_PhosCatIridiumIII_CCBY-VoR
Copyright 2018 the Authors. This Open Access article is licensed under a Creative Commons Attribution 3.0 Unported Licence
Final published version, 700 KBLicence: CC BY

Blue-Emitting Phospors: Blue-emitting Phosphors for Solid State Lighting Applications
Zysman-Colman, E. (PI)
EPSRC
1/06/15 → 30/09/19
Project: Standard

Phosphorescent Cationic Iridium(III) Complexes Dynamically Bound to Cyclodextrin Vesicles: Applications in Live Cell Imaging (dataset)
Schibilla, F. (Creator), Holthenrich, A. (Creator), Song, B. (Creator), Linard Matos, A. L. (Creator), Grill, D. (Creator), Rota Martir, D. (Creator), Gerke, V. (Creator), Zysman-Colman, E. (Creator) & Ravoo, B. J. (Creator), University of St Andrews, 27 Aug 2018
DOI: 10.17630/1254db92-71d2-45a6-ac87-247894110d66
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@article{5b5e51a323994bff9238db32b8c1f292,

title = "Phosphorescent cationic iridium(III) complexes dynamically bound to cyclodextrin vesicles: applications in live cell imaging",

abstract = "We report cationic Ir(III) complexes functionalized with adamantyl groups designed to bind to β-cyclodextrin vesicles (CDV) with high affinity (Ka = 1·106 M-1). The emission of the complexes is tuned by changing the nature of the cyclometalating ligands. The host-guest adduct of CDV and Ir(III) complexes shows increased and significantly blue-shifted emission due to the lower mobility of the Ir(III)-complexes residing in the less polar environment of the vesicle surface. Ir(III)-decorated CDV are efficiently taken up by cells and can be used in live cell imaging. The CDV act as carriers to transport the phosphorescent complexes into cells where they selectively stain mitochondria.",

author = "Frauke Schibilla and Anna Holthenrich and Boyi Song and {Linard Matos}, {Anna L{\'i}via} and David Grill and {Rota Martir}, Diego and Volker Gerke and Eli Zysman-Colman and Ravoo, {Bart Jan}",

note = "The authors are grateful for financial support by the Deutsche Forschungsgemeinschaft (DFG Ra 1732/7, SFB 858 and Ge 514/6) and Deutscher Akademischer Austauschdienst (DAAD). E.Z.-C. acknowledges the University of St. Andrews and EPSRC (EP/M02105X/1) for financial support.",

year = "2018",

month = oct,

day = "28",

doi = "10.1039/C8SC02875C",

language = "English",

volume = "9",

pages = "7822--7828",

journal = "Chemical Science",

issn = "2041-6520",

publisher = "Royal Society of Chemistry",

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TY - JOUR

T1 - Phosphorescent cationic iridium(III) complexes dynamically bound to cyclodextrin vesicles

T2 - applications in live cell imaging

AU - Schibilla, Frauke

AU - Holthenrich, Anna

AU - Song, Boyi

AU - Linard Matos, Anna Lívia

AU - Grill, David

AU - Rota Martir, Diego

AU - Gerke, Volker

AU - Zysman-Colman, Eli

AU - Ravoo, Bart Jan

N1 - The authors are grateful for financial support by the Deutsche Forschungsgemeinschaft (DFG Ra 1732/7, SFB 858 and Ge 514/6) and Deutscher Akademischer Austauschdienst (DAAD). E.Z.-C. acknowledges the University of St. Andrews and EPSRC (EP/M02105X/1) for financial support.

PY - 2018/10/28

Y1 - 2018/10/28

N2 - We report cationic Ir(III) complexes functionalized with adamantyl groups designed to bind to β-cyclodextrin vesicles (CDV) with high affinity (Ka = 1·106 M-1). The emission of the complexes is tuned by changing the nature of the cyclometalating ligands. The host-guest adduct of CDV and Ir(III) complexes shows increased and significantly blue-shifted emission due to the lower mobility of the Ir(III)-complexes residing in the less polar environment of the vesicle surface. Ir(III)-decorated CDV are efficiently taken up by cells and can be used in live cell imaging. The CDV act as carriers to transport the phosphorescent complexes into cells where they selectively stain mitochondria.

AB - We report cationic Ir(III) complexes functionalized with adamantyl groups designed to bind to β-cyclodextrin vesicles (CDV) with high affinity (Ka = 1·106 M-1). The emission of the complexes is tuned by changing the nature of the cyclometalating ligands. The host-guest adduct of CDV and Ir(III) complexes shows increased and significantly blue-shifted emission due to the lower mobility of the Ir(III)-complexes residing in the less polar environment of the vesicle surface. Ir(III)-decorated CDV are efficiently taken up by cells and can be used in live cell imaging. The CDV act as carriers to transport the phosphorescent complexes into cells where they selectively stain mitochondria.

U2 - 10.1039/C8SC02875C

DO - 10.1039/C8SC02875C

M3 - Article

AN - SCOPUS:85055494338

SN - 2041-6520

VL - 9

SP - 7822

EP - 7828

JO - Chemical Science

JF - Chemical Science

IS - 40

ER -

Phosphorescent cationic iridium(III) complexes dynamically bound to cyclodextrin vesicles: applications in live cell imaging

Abstract

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Blue-Emitting Phospors: Blue-emitting Phosphors for Solid State Lighting Applications

Datasets

Phosphorescent Cationic Iridium(III) Complexes Dynamically Bound to Cyclodextrin Vesicles: Applications in Live Cell Imaging (dataset)

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