Phospholipases A1

Gregory S. Richmond, Terry K. Smith

Research output: Contribution to journalReview articlepeer-review

150 Citations (Scopus)
2 Downloads (Pure)

Abstract

Phospholipase A1 (PLA1) is an enzyme that hydrolyzes phospholipids and produces 2-acyl-lysophospholipids and fatty acids. This lipolytic activity is conserved in a wide range of organisms but is carried out by a diverse set of PLA1 enzymes. Where their function is known, PLA1s have been shown to act as digestive enzymes, possess central roles in membrane maintenance and remodeling, or regulate important cellular mechanisms by the production of various lysophospholipid mediators, such as lysophosphatidylserine and lysophosphatidic acid, which in turn have multiple biological functions.

Original languageEnglish
Pages (from-to)588-612
Number of pages25
JournalInternational Journal of Molecular Sciences
Volume12
Issue number1
DOIs
Publication statusPublished - Jan 2011

Keywords

  • Phospholipase A(1)
  • Phospholipid
  • Lysophospholipid
  • Mammalian sec23p-interacting protein
  • Platelet-activating-factor
  • Pig heart microsomes
  • Lipase gene family
  • Phosphatidic-acid
  • Arachidonic-acid
  • Trypanosoma-brucei
  • Escherichia-coli
  • Bovine brain
  • Guinea-pig

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