Phospholipases A1

Gregory S. Richmond; Terry K. Smith

doi:10.3390/ijms12010588

Phospholipases A₁

Gregory S. Richmond, Terry K. Smith

Research output: Contribution to journal › Review article › peer-review

Abstract

Phospholipase A₁ (PLA₁) is an enzyme that hydrolyzes phospholipids and produces 2-acyl-lysophospholipids and fatty acids. This lipolytic activity is conserved in a wide range of organisms but is carried out by a diverse set of PLA₁ enzymes. Where their function is known, PLA₁s have been shown to act as digestive enzymes, possess central roles in membrane maintenance and remodeling, or regulate important cellular mechanisms by the production of various lysophospholipid mediators, such as lysophosphatidylserine and lysophosphatidic acid, which in turn have multiple biological functions.

Original language	English
Pages (from-to)	588-612
Number of pages	25
Journal	International Journal of Molecular Sciences
Volume	12
Issue number	1
DOIs	https://doi.org/10.3390/ijms12010588
Publication status	Published - Jan 2011

Keywords

Phospholipase A(1)
Phospholipid
Lysophospholipid
Mammalian sec23p-interacting protein
Platelet-activating-factor
Pig heart microsomes
Lipase gene family
Phosphatidic-acid
Arachidonic-acid
Trypanosoma-brucei
Escherichia-coli
Bovine brain
Guinea-pig

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10.3390/ijms12010588

SmithIntJMolSci2011Phospholipases
© 2011 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
Final published version, 421 KB

Validating choline metabolism WT: validating choline metabolism as a drug target in the fight against T Brucei
Smith, T. K. (PI)
The Wellcome Trust
1/12/09 → 30/11/11
Project: Standard

Cite this

@article{4e501b9b7a2042dd97aa189005c58753,

title = "Phospholipases A1",

abstract = "Phospholipase A1 (PLA1) is an enzyme that hydrolyzes phospholipids and produces 2-acyl-lysophospholipids and fatty acids. This lipolytic activity is conserved in a wide range of organisms but is carried out by a diverse set of PLA1 enzymes. Where their function is known, PLA1s have been shown to act as digestive enzymes, possess central roles in membrane maintenance and remodeling, or regulate important cellular mechanisms by the production of various lysophospholipid mediators, such as lysophosphatidylserine and lysophosphatidic acid, which in turn have multiple biological functions.",

keywords = "Phospholipase A(1), Phospholipid, Lysophospholipid, Mammalian sec23p-interacting protein, Platelet-activating-factor, Pig heart microsomes, Lipase gene family, Phosphatidic-acid, Arachidonic-acid, Trypanosoma-brucei, Escherichia-coli, Bovine brain, Guinea-pig",

author = "Richmond, {Gregory S.} and Smith, {Terry K.}",

note = "Research in the author's laboratory is supported in part by a Wellcome Trust Senior Research Fellowship (067441), and Wellcome Trust project grants (086658 and 093228) and a Wellcome Trust Prize Studentship (G.S.R).",

year = "2011",

month = jan,

doi = "10.3390/ijms12010588",

language = "English",

volume = "12",

pages = "588--612",

journal = "International Journal of Molecular Sciences",

issn = "1422-0067",

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TY - JOUR

T1 - Phospholipases A1

AU - Richmond, Gregory S.

AU - Smith, Terry K.

N1 - Research in the author's laboratory is supported in part by a Wellcome Trust Senior Research Fellowship (067441), and Wellcome Trust project grants (086658 and 093228) and a Wellcome Trust Prize Studentship (G.S.R).

PY - 2011/1

Y1 - 2011/1

N2 - Phospholipase A1 (PLA1) is an enzyme that hydrolyzes phospholipids and produces 2-acyl-lysophospholipids and fatty acids. This lipolytic activity is conserved in a wide range of organisms but is carried out by a diverse set of PLA1 enzymes. Where their function is known, PLA1s have been shown to act as digestive enzymes, possess central roles in membrane maintenance and remodeling, or regulate important cellular mechanisms by the production of various lysophospholipid mediators, such as lysophosphatidylserine and lysophosphatidic acid, which in turn have multiple biological functions.

AB - Phospholipase A1 (PLA1) is an enzyme that hydrolyzes phospholipids and produces 2-acyl-lysophospholipids and fatty acids. This lipolytic activity is conserved in a wide range of organisms but is carried out by a diverse set of PLA1 enzymes. Where their function is known, PLA1s have been shown to act as digestive enzymes, possess central roles in membrane maintenance and remodeling, or regulate important cellular mechanisms by the production of various lysophospholipid mediators, such as lysophosphatidylserine and lysophosphatidic acid, which in turn have multiple biological functions.

KW - Phospholipase A(1)

KW - Phospholipid

KW - Lysophospholipid

KW - Mammalian sec23p-interacting protein

KW - Platelet-activating-factor

KW - Pig heart microsomes

KW - Lipase gene family

KW - Phosphatidic-acid

KW - Arachidonic-acid

KW - Trypanosoma-brucei

KW - Escherichia-coli

KW - Bovine brain

KW - Guinea-pig

U2 - 10.3390/ijms12010588

DO - 10.3390/ijms12010588

M3 - Review article

SN - 1422-0067

VL - 12

SP - 588

EP - 612

JO - International Journal of Molecular Sciences

JF - International Journal of Molecular Sciences

IS - 1

ER -

Phospholipases A1

Abstract

Keywords

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Projects

Validating choline metabolism WT: validating choline metabolism as a drug target in the fight against T Brucei

Cite this

Phospholipases A₁