Periplasmic export machines for outer membrane assembly

Chris Whitfield, James H. Naismith

Research output: Contribution to journalReview articlepeer-review

16 Citations (Scopus)

Abstract

The cell envelope of Gram-negative bacteria protects the organism from environmental stresses, components of the innate immune response, and the actions of other antagonistic molecules. However, the complexity of the cell envelope dictated by these protective roles creates a significant challenge for assembly of the outer membrane. Extensive research has focused on the export and assembly of outer membrane proteins and there is continuing progress in this area. By contrast, knowledge of the export and assembly of complex glycoconjugates in the outer membrane has been limited until recently. New structural and biochemical information identifies an envelope-spanning molecular scaffold for the export of group 1 capsular polysaccharides and provides insight into a complex molecular machine.

Original languageEnglish
Pages (from-to)466-474
Number of pages9
JournalCurrent Opinion in Structural Biology
Volume18
DOIs
Publication statusPublished - Aug 2008

Keywords

  • GROUP-1 CAPSULAR POLYSACCHARIDES
  • TYROSINE-KINASE WZC
  • ESCHERICHIA-COLI
  • MULTIDRUG EFFLUX
  • CRYSTAL-STRUCTURE
  • CHAPERONE SKP
  • LIPOPOLYSACCHARIDE TRANSPORT
  • ELECTRON-MICROSCOPY
  • INNER MEMBRANE
  • SECRETIN PULD

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